Strong Circadian Rhythms in the Choroid Plexus: Implications for Sleep-Independent Brain Metabolite Clearance

Journal of Experimental Neuroscience
Jihwan MyungTimothy Joseph Lane

Abstract

Cerebrospinal fluid (CSF) is a fluidic part of the brain's microenvironment that isolates the brain from the rest of the body. CSF dilutes metabolites from neuronal activities and removes them from the brain. Its production and resorption are regulated dynamically and are central to maintaining brain homeostasis. We discovered that the major CSF source, the choroid plexus (CP), harbors the brain's strongest circadian clock. Here, we consider some implications of the CP circadian clock for metabolite clearance in the brain. If the circadian clock contributes to timed production of the CSF, its synchronization with sleep timing can maximize clearance efficiency and help prevent neurodegenerative diseases such as Alzheimer's disease.

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Citations

Dec 12, 2019·Journal of Neuroscience Research·Daniela TalhadaCecília Reis Alves Santos
Feb 6, 2019·Fluids and Barriers of the CNS·Richard F KeepLester R Drewes
Sep 23, 2020·International Journal of Molecular Sciences·Ana C DuarteCecília R A Santos
Dec 4, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina PolaskyRalph Pries
Aug 4, 2021·Progress in Neurobiology·Telma QuintelaCecília R A Santos
Aug 5, 2020·Biochimica Et Biophysica Acta. Biomembranes·Ingrid KratzerHelen Stolp

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