Strong correlation between serum aspergillus galactomannan index and outcome of aspergillosis in patients with hematological cancer: clinical and research implications

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Marisa H MiceliElias J Anaissie

Abstract

Galactomannan is an Aspergillus-specific polysaccharide released during aspergillosis and is detected by the quantitative serum galactomannan index (GMI) test. Preclinical and preliminary clinical reports have suggested a good correlation between GMI and aspergillosis outcome. We reviewed the literature to assess the strength of correlation between GMI and aspergillosis outcome using the kappa correlation coefficient. We included 27 studies that enrolled patients with hematological cancer and proven or probable aspergillosis and that used sequential GMI testing. We examined the 3 following outcomes: survival (survival vs. death), global outcome (survival vs. death [including autopsy findings]), and autopsy outcome (autopsy findings only). Overall, 257 patients fulfilled criteria for proven or probable aspergillosis and were eligible for outcome evaluation. Correlation between GMI (within <or=1 week before outcome) and defined outcomes was excellent, with kappa correlation coefficients of 0.8737 (95% confidence interval, 0.8140-0.9333; P<.001) and 0.9123 (95% confidence interval, 0.8617-0.9629; P<.001) for survival and global outcome, respectively. Most importantly, the kappa correlation coefficient for autopsy outcome was high ...Continue Reading

References

Jun 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S BretagneC Cordonnier
Dec 1, 1999·Bone Marrow Transplantation·U MachidaH Hirai
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M MachettiC Viscoli
Oct 6, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M KamiH Hirai
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S AsciogluUNKNOWN Mycoses Study Group of the National Institute of Allergy and Infectious Diseases
Feb 16, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·M E GarciaJ L Blanco
Mar 7, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·François BoutboulPatricia Ribaud
Mar 29, 2002·The Hematology Journal : the Official Journal of the European Haematology Association·A UlusakaryaJ N Munck
Apr 23, 2002·Journal of Clinical Laboratory Analysis·S Centeno-LimaF Exposto
Jul 12, 2002·Statistics in Medicine·Helena Chmura KraemerArt Noda
Aug 9, 2002·The New England Journal of Medicine·Raoul HerbrechtUNKNOWN Invasive Fungal Infections Group of the European Organisation for Research and Treatment of Cancer and the Global Aspergillu
Feb 28, 2004·Transplant Infectious Disease : an Official Journal of the Transplantation Society·L J Wheat
Jan 18, 2005·Clinical Microbiology Reviews·Nina Singh, David L Paterson
Oct 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Johan MaertensJohan Van Eldere
Dec 26, 2006·Expert Review of Molecular Diagnostics·Virginia VerdaguerKaroll J Cortez
Jan 26, 2007·The New England Journal of Medicine·Andrew J UllmannSimon Durrant
Jan 26, 2007·The New England Journal of Medicine·Oliver A CornelyDavid Angulo-Gonzalez
Apr 20, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E J Anaissie

❮ Previous
Next ❯

Citations

Oct 15, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H-C HsiueP-R Hsueh
Mar 3, 2009·Medical Mycology·Marisa Miceli, Elias Anaissie
Oct 24, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Julio García-RodríguezDaniel Borches
Jan 5, 2011·The Journal of Antimicrobial Chemotherapy·Manuel Cuenca-EstrellaThomas R Rogers
Jan 5, 2011·The Journal of Antimicrobial Chemotherapy·Johan MaertensOscar Marchetti
Apr 9, 2010·Current Opinion in Pulmonary Medicine·Rami Sherif, Brahm H Segal
Jan 22, 2011·Current Opinion in Pulmonary Medicine·Louis Yi-Ann Chai, Li-Yang Hsu
Oct 4, 2008·Current Opinion in Hematology·Valerio Del BonoClaudio Viscoli
Feb 18, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jeannina A Smith, Carol A Kauffman
Feb 12, 2010·Journal of Clinical Microbiology·Sophia KooFrancisco M Marty
Oct 7, 2011·Journal of Clinical Microbiology·Ruta PetraitieneThomas J Walsh
May 4, 2012·Journal of Clinical Microbiology·Louis Y A ChaiRaoul Herbrecht
Aug 13, 2010·Clinical Medicine Insights. Oncology·Rodrigo Lopes da SilvaAida Botelho de Sousa
Sep 21, 2013·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Indranil GhoshSobuhi Iqbal
Mar 17, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Simone Aranha NouérElias Anaissie
Aug 19, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Simone A NouérElias Anaissie
Feb 20, 2013·Current Fungal Infection Reports·C Orla Morrissey
Nov 12, 2014·Expert Review of Anti-infective Therapy·Małgorzata MikulskaClaudio Viscoli
Nov 15, 2015·Journal of Veterinary Internal Medicine·V K CorriganL Cepero
Jun 2, 2010·Current Medical Research and Opinion·William J Steinbach
May 3, 2013·Current Medical Research and Opinion·John R Perfect
May 27, 2014·Clinics in Laboratory Medicine·Frédéric Lamoth, Barbara D Alexander
Aug 13, 2013·Clinics in Laboratory Medicine·Audrey N Schuetz
Sep 25, 2012·Burns : Journal of the International Society for Burn Injuries·Dana M BlythClinton K Murray
Mar 9, 2012·Enfermedades infecciosas y microbiología clínica·Manuel Cuenca-Estrella
Dec 14, 2011·Médecine et maladies infectieuses·M P GerlingerO Eloy
Feb 8, 2011·Clinics in Laboratory Medicine·Carolyn Cray
Apr 21, 2009·Clinics in Chest Medicine·L Joseph Wheat
Dec 2, 2008·Best Practice & Research. Clinical Haematology·Elias J Anaissie
Dec 13, 2012·Annals of the New York Academy of Sciences·Sarah P Georgiadou, Dimitrios P Kontoyiannis
Mar 6, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S Y ParkS-O Lee
Jun 1, 2010·American Journal of Hematology·Yasuo MoriTakanori Teshima
Oct 2, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S AntinoriA M Gianni
May 14, 2010·Mycoses·R Kappe, D Rimek
Jan 4, 2012·The American Journal of Medicine·Luis Ostrosky-Zeichner
Jan 4, 2012·The American Journal of Medicine·John R Perfect

❮ Previous
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