Strong correlation of basement membrane degradation with p53 inactivation and/or MDM2 overexpression in superficial urothelial carcinomas

The Journal of Urology
E OzdemirO Yoshida

Abstract

We investigated the relationships between the degradation of basement membrane underlying superficial urothelial carcinomas, including carcinoma in situ and the functional p53 loss caused by inactivation of p53 and the overexpression of mdm2 oncoprotein. Nuclear accumulations of p53 and mdm2 were examined immunohistochemically for 60 transitional cell carcinomas (primary lesions) and 13 accompanying (concomitant) carcinoma in situ lesions. Degradation of the basement membrane was defined as the reduction or total loss of type IV collagen expression. Whether there was up-regulation of MMP-1, MMP-2, and MMP-9 was analyzed immunohistochemically. The frequency of the degradation of basement membrane underlying grade 1 pTa tumors was 0%, grade 2-3 pTa tumors 57.1%, and primary CIS lesions 83.3%. Nuclear over-accumulation of p53 was found in 48.3% and of mdm2 in 23.3% of the primary tumors. In pTa-pT1 carcinomas, nuclear staining of p53, mdm2, or both was highly correlated with degradation of the basement membrane underlying carcinomas (p = 0.00002). In the CIS lesions, the association of p53 nuclear staining with the destruction of type IV collagen expression was of borderline significance (p = 0.03). When mdm2 overexpression was co...Continue Reading

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Citations

Dec 15, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Shuichi KamijimaHaruo Ito
Aug 2, 2012·ISRN Urology·O Rodriguez FabaF J Vizoso
May 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·K R LeiteL H Camara-Lopes
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May 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jin BaiZhen-Qiang Pan
Mar 25, 2014·Cancer Discovery·Emily PowellHelen Piwnica-Worms
May 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gangqiao ZhouFuchu He
Jun 11, 2021·Annals of Diagnostic Pathology·Mariana Bonjiorno MartinsLaura Sterian Ward

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