Strong electroactive biodegradable shape memory polymer networks based on star-shaped polylactide and aniline trimer for bone tissue engineering

ACS Applied Materials & Interfaces
Meihua XiePeter X Ma

Abstract

Preparation of functional shape memory polymer (SMP) for tissue engineering remains a challenge. Here the synthesis of strong electroactive shape memory polymer (ESMP) networks based on star-shaped polylactide (PLA) and aniline trimer (AT) is reported. Six-armed PLAs with various chain lengths were chemically cross-linked to synthesize SMP. After addition of an electroactive AT segment into the SMP, ESMP was obtained. The polymers were characterized by (1)H NMR, GPC, FT-IR, CV, DSC, DMA, tensile test, and degradation test. The SMP and ESMP exhibited strong mechanical properties (modulus higher than GPa) and excellent shape memory performance: short recovery time (several seconds), high recovery ratio (over 94%), and high fixity ratio (almost 100%). Moreover, cyclic voltammetry test confirmed the electroactivity of the ESMP. The ESMP significantly enhanced the proliferation of C2C12 cells compared to SMP and linear PLA (control). In addition, the ESMP greatly improved the osteogenic differentiation of C2C12 myoblast cells compared to PH10 and PLA in terms of ALP enzyme activity, immunofluorescence staining, and relative gene expression by quantitative real-time polymerase chain reaction (qRT-PCR). These intelligent SMPs and elec...Continue Reading

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Citations

Jun 6, 2016·Advanced Drug Delivery Reviews·Maria BalkAndreas Lendlein
Nov 5, 2016·Colloids and Surfaces. B, Biointerfaces·Dan KaiXian Jun Loh
Jul 12, 2017·ACS Applied Materials & Interfaces·Xin ZhangXibo Pei
Sep 25, 2017·Advanced Healthcare Materials·Gregory I PetersonMatthew L Becker
May 18, 2018·Soft Matter·Ruiqing WuXiaobin Ding
Nov 1, 2018·Frontiers of Medicine·Bo LeiPeter X Ma
Jan 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bing XueEugenia Kharlampieva
Jan 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Longchao LiBaolin Guo
Apr 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing ChenPeter X Ma
Oct 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tianyi ZhengXiaoping Yang
Nov 12, 2019·Bioactive Materials·Maria P Nikolova, Murthy S Chavali
Oct 27, 2020·Bioactive Materials·Sophie Wendels, Luc Avérous
Feb 3, 2019·Acta Biomaterialia·Qingzheng ZhangXuesi Chen
Sep 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Melika NourbakhshMohammad Reza Saeb
May 11, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Michaela R Pfau, Melissa A Grunlan
Jun 21, 2020·International Journal of Biological Macromolecules·Bryan D JamesJosephine B Allen
Dec 15, 2016·ACS Applied Materials & Interfaces·Xiaoshan FanXian Jun Loh
Mar 29, 2016·ACS Applied Materials & Interfaces·Benjamin Qi Yu ChanXian Jun Loh
Sep 9, 2019·ACS Biomaterials Science & Engineering·Zhengnan ZhouGuoxin Tan
Apr 24, 2018·Biomacromolecules·Baolin Guo, Peter X Ma
Jul 20, 2018·ACS Omega·Aruã C da SilvaSusana I Cordoba de Torresi
Jul 10, 2018·Progress in Polymer Science·Chengyun NingChuanbin Mao

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