Strong heterogeneity of outcome reporting in systematic reviews

Journal of Clinical Epidemiology
Bénédicte SautenetBruno Giraudeau

Abstract

The Core Outcome Measures in Effectiveness Trial initiative aims at developing core outcome set (COS) for research. Consensus on a COS for renoprotection research is lacking. We performed a systematic review (SR) of SRs of renoprotection to identify outcomes used in renoprotection research and to assess how frequently these outcomes could be meta-analyzed in the SRs. We searched for SRs with meta-analyses of renoprotection treatments in the Database of Abstracts of Reviews of Effects and in MEDLINE and collected outcomes that were meta-analyzed. For each outcome and SR, we assessed the proportion of trials/patients that could be meta-analyzed. We retrieved 66 SRs. A total of 609 outcomes were extracted for 20 distinct renoprotection outcomes. The median (interquartile range) proportion of SRs in which these outcomes had been meta-analyzed was 8% (2%, 27%) (range 2-50%). The proportion of trials that had been aggregated was >75% for only 36% of the outcomes. The outcomes meta-analyzed in renoprotection trials are heterogeneous, with a low proportion of trials or patients pooled for each outcome and each SR. A COS is needed in renoprotection research to limit this waste of research. The outcomes identified in the present work cou...Continue Reading

References

Oct 1, 1996·Annals of Internal Medicine·T R Fleming, D L DeMets
Jan 5, 2000·Kidney International·L A Hebert
Mar 22, 2001·Kidney International·L A HebertB H Rovin
May 22, 2003·JAMA : the Journal of the American Medical Association·Nick FreemantleCarl Griffin
Dec 28, 2004·BMJ : British Medical Journal·Victor M MontoriUNKNOWN Hedges Team
Mar 12, 2005·BMJ : British Medical Journal·Victor M MontoriGordon H Guyatt
Apr 4, 2007·BMJ : British Medical Journal·Ignacio Ferreira-GonzálezGordon H Guyatt
Jul 7, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrew S LeveyThomas Hostetter
Aug 4, 2009·Lancet·Claire F Snyder, Neil K Aaronson
Aug 20, 2010·BMJ : British Medical Journal·Jeppe Lerche la CourPeter C Gøtzsche
Aug 20, 2010·BMJ : British Medical Journal·Gloria CordobaPeter C Gøtzsche
Jul 23, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Aneet DeoKatrin Uhlig
Aug 13, 2011·Nephron. Clinical Practice·H J Lambers HeerspinkD de Zeeuw
Aug 20, 2011·Fundamental & Clinical Pharmacology·Jean-Michel HalimiBruno Giraudeau
Mar 1, 2012·Advances in Chronic Kidney Disease·Joshua A Samuels, Donald A Molony
Aug 8, 2012·Trials·Paula R WilliamsonPeter Tugwell
Jan 30, 2013·BMJ : British Medical Journal·Nick Black
Jul 3, 2013·Journal of Clinical Epidemiology·Bénédicte SautenetBruno Giraudeau
Jul 11, 2013·JAMA : the Journal of the American Medical Association·Ethan BaschKaren Adams
Nov 26, 2013·BMJ : British Medical Journal·David Prieto-MerinoIan Roberts
May 17, 2014·Statistics in Medicine·Abdul J SankohRalph B D'Agostino
Jul 12, 2014·Trials·Elizabeth GargonMike Clarke
Nov 25, 2014·BMJ : British Medical Journal·Pooja SainiJamie J Kirkham
Dec 3, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrew S LeveyJosef Coresh
Dec 3, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lesley A InkerAndrew S Levey
Dec 3, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hiddo J Lambers HeerspinkLesley A Inker
Jan 4, 2015·Journal of the American Society of Nephrology : JASN·Min JunBrenda R Hemmelgarn

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Citations

Aug 3, 2017·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Karine E ManeraUNKNOWN SONG-PD Investigators

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