DOI: 10.1101/503995Dec 21, 2018Paper

Strong selective sweeps before 45,000BP displaced archaic admixture across the human X chromosome

BioRxiv : the Preprint Server for Biology
Laurits SkovKasper Munch

Abstract

The X chromosome in non-African populations has less diversity and less Neanderthal introgression than expected. We analyzed X chromosome diversity across the globe and discovered seventeen chromosomal regions, where haplotypes of several hundred kilobases have recently reached high frequencies in non-African populations only. The selective sweeps must have occurred more than 45,000 years ago because the ancient Ust'-Ishim male also carries its expected proportion of these haplotypes. Surprisingly, the swept haplotypes are entirely devoid of Neanderthal introgression, which implies that a population without Neanderthal admixture contributed the swept haplotypes. It also implies that the sweeps must have happened after the main interbreeding event with Neanderthals about 55,000 BP. These swept haplotypes may thus be the only genetic remnants of an earlier out-of-Africa event.

Related Concepts

Blood Pressure
Chromosomes
X Chromosome
Analysis
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Gene Flow
Atypichthys strigatus
Region of Chromosome

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