Strong somatic stimulation differentially regulates the firing properties of prefrontal cortex neurons.

Brain Research
Lourdes Nogueira, Antonieta Lavin

Abstract

Among the brain structures involved in processing affective stimuli, the roles of the prefrontal cortex (PFC) and the mesocorticolimbic dopaminergic (DA) innervation are well established. In contrast to our understanding of the reward stimuli, less is known about how strong somatic stimulation is processed within the PFC. Here, we examined the effects of a strong pinch delivered to the rat posterior paw on spontaneous and current-evoked activity of PFC neurons using intracellular recordings in anesthetized rats. Following the paw pinch, pyramidal cells exhibited a significant decrease in spontaneous activity along with a significant increase in the current-evoked firing. The increase in current-evoked firing elicited by the paw pinch was inversely correlated with the baseline firing rate. Systemic administration of a selective dopamine D2 receptor antagonist partially blocked the effects elicited by the paw pinch on cortical excitability, whereas systemic administration of a D1 antagonist seems to facilitate paw-mediated increases in evoked firing. These results suggest that strong somatic stimuli decrease spontaneous firing while increasing depolarization-evoked firing in a DA receptor dependent manner. These mechanisms may he...Continue Reading

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May 20, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Antonieta LavinJeremy K Seamans
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Nov 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lourdes NogueiraAntonieta Lavin

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