Stronger efferent suppression of cochlear neural potentials by contralateral acoustic stimulation in awake than in anesthetized chinchilla

Frontiers in Systems Neuroscience
Cristian AedoLuis Robles

Abstract

There are two types of sensory cells in the mammalian cochlea, inner hair cells, which make synaptic contact with auditory-nerve afferent fibers, and outer hair cells that are innervated by crossed and uncrossed medial olivocochlear (MOC) efferent fibers. Contralateral acoustic stimulation activates the uncrossed efferent MOC fibers reducing cochlear neural responses, thus modifying the input to the central auditory system. The chinchilla, among all studied mammals, displays the lowest percentage of uncrossed MOC fibers raising questions about the strength and frequency distribution of the contralateral-sound effect in this species. On the other hand, MOC effects on cochlear sensitivity have been mainly studied in anesthetized animals and since the MOC-neuron activity depends on the level of anesthesia, it is important to assess the influence of anesthesia in the strength of efferent effects. Seven adult chinchillas (Chinchilla laniger) were chronically implanted with round-window electrodes in both cochleae. We compared the effect of contralateral sound in awake and anesthetized condition. Compound action potentials (CAP) and cochlear microphonics (CM) were measured in the ipsilateral cochlea in response to tones in absence an...Continue Reading

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Citations

Oct 21, 2015·Frontiers in Systems Neuroscience·Gonzalo Terreros, Paul H Delano
Apr 20, 2017·Frontiers in Neuroscience·Spencer B SmithBarbara K Cone
Dec 8, 2017·Frontiers in Cellular Neuroscience·Paul D Allen, Anne E Luebke
Jun 24, 2017·Frontiers in Neuroscience·Eric VerschootenPhilip X Joris
Apr 11, 2018·Frontiers in Neurology·Enrique A Lopez-Poveda
Mar 7, 2021·Hearing Research·Amanda M LauerPaul H Delano
Oct 21, 2021·PLoS Biology·Heivet Hernández-PérezCatherine M McMahon

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