PMID: 11902338Mar 21, 2002Paper

Stronger proliferative response to membrane versus cell-wall Streptococcal proteins by peripheral blood T cells in chronic plaque psoriasis

Scandinavian Journal of Immunology
B S BakerL Fry

Abstract

Proliferative responses of peripheral blood mononuclear cells (PBMC) to group A streptococcal (GAS) antigens have been studied in 24 patients with psoriasis and 15 disease controls. Extracts of cell wall (including M protein) from types M4 and M12 GAS, recombinant M6 protein, and both cell-wall and cell-membrane extracts from type M6 (M6+) GAS and its corresponding M gene deletion mutant (M6-) were tested. PBMC from psoriatic patients proliferated more strongly to cell-wall extracts from M12 versus M4 (P = 0.0348), and to M6+ versus M6- (P = 0.0019) GAS with, in most cases, moderate proliferation to recombinant M6 protein. The psoriatic response to M12 cell wall was significantly increased compared to the controls (P = 0.0032). In psoriatics, M6+ membrane extracts induced a markedly greater proliferation than those of cell wall (P = 0.0002); responses to M6+ (P = 0.0039) and M6- (P = 0.0114) membrane extracts were higher than those of the control PBMC. Both groups showed a decreased response to the M6- versus M6+ membrane extracts (P = 0.0030; P = 0.0181, respectively). This study has demonstrated that patients with psoriasis have a heightened circulating T-cell response to cell wall M protein and to non-M proteins present on t...Continue Reading

References

Nov 1, 1977·The British Journal of Dermatology·W L GrossM Schlaak
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·E Hanski, M Caparon
Jan 1, 1992·Archives of Dermatology·N R TelferG Colman
Jun 1, 1985·The Journal of Experimental Medicine·V A FischettiJ R Scott
Jul 1, 1989·Clinical Microbiology Reviews·V A Fischetti
Apr 1, 1988·The British Journal of Dermatology·C A Henderson, A S Highet
Jul 1, 1974·Infection and Immunity·J B Woolcock
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H K Ziegler, E R Unanue
May 1, 1993·The British Journal of Dermatology·B S BakerL Fry
May 1, 1998·Clinical Otolaryngology and Allied Sciences·P WardropG Kavanagh
Nov 10, 1998·Archives of Dermatological Research·T Henseler
Mar 6, 1999·Microbiology and Molecular Biology Reviews : MMBR·W W Navarre, O Schneewind
May 4, 1999·The Journal of Clinical Investigation·J B DaleD L Hasty
Nov 7, 1999·Archives of Dermatological Research·B S BakerL Fry
Oct 18, 2000·Infection and Immunity·M RasmussenL Björck

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Citations

Apr 28, 2005·Archives of Dermatological Research·P Weisenseel, J C Prinz
Dec 21, 2007·Clinical Reviews in Allergy & Immunology·Brian J NickoloffFrank O Nestle
Dec 13, 2006·Clinical & Developmental Immunology·Lionel FryAnne V Powles
May 17, 2006·International Journal of Dermatology·Rolando Pérez-LorenzoGuadalupe Bricaire-Bricaire
Sep 14, 2011·The British Journal of Dermatology·J SkavlandJ A Marcusson

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