Strongly Accelerated Margination of Active Particles in Blood Flow

Biophysical Journal
Stephan Gekle

Abstract

Synthetic nanoparticles and other stiff objects injected into a blood vessel filled with red blood cells are known to marginate toward the vessel walls. By means of hydrodynamic lattice-Boltzmann simulations, we show that active particles can strongly accelerate their margination by moving against the flow direction: particles located initially in the channel center migrate much faster to their final position near the wall than in the nonactive case. We explain our findings by an enhanced rate of collisions between the stiff particles and the deformable red blood cells. Our results imply that a significantly faster margination can be achieved either technically by the application of an external magnetic field (if the particles are magnetic) or biologically by self-propulsion (if the particles are, e.g., swimming bacteria).

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Citations

Feb 28, 2017·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Achim Guckenberger, Stephan Gekle
Feb 7, 2018·The European Physical Journal. E, Soft Matter·Abdallah Daddi-Moussa-Ider, Stephan Gekle
Feb 18, 2017·Physical Review. E·Abdallah Daddi-Moussa-Ider, Stephan Gekle
Jun 30, 2019·The European Physical Journal. E, Soft Matter·Livio Nicola CarenzaAdriano Tiribocchi
Jan 1, 2017·Microfluidics and Nanofluidics·A CocliteP Decuzzi
Jul 25, 2019·Physical Review. E·Christian Bächer, Stephan Gekle
Sep 9, 2018·The European Physical Journal. E, Soft Matter·Abdallah Daddi-Moussa-IderStephan Gekle
Jul 10, 2018·The Journal of Chemical Physics·Abdallah Daddi-Moussa-IderHartmut Löwen
Jun 18, 2017·Physical Review. E·Abdallah Daddi-Moussa-IderStephan Gekle
Oct 20, 2020·PLoS Computational Biology·Iveta JančigováIvan Cimrák

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