Strongyloides seroprevalence before and after an ivermectin mass drug administration in a remote Australian Aboriginal community

PLoS Neglected Tropical Diseases
Thérèse M KearnsRoss M Andrews

Abstract

Strongyloides seroprevalence is hyper-endemic in many Australian Aboriginal and Torres Strait Islander communities, ranging from 35-60%. We report the impact on Strongyloides seroprevalence after two oral ivermectin mass drug administrations (MDAs) delivered 12 months apart in a remote Australian Aboriginal community. Utilizing a before and after study design, we measured Strongyloides seroprevalence through population census with sequential MDAs at baseline and month 12. Surveys at months 6 and 18 determined changes in serostatus. Serodiagnosis was undertaken by ELISA that used sonicated Strongyloides ratti antigen to detect anti-Strongyloides IgG. Non-pregnant participants weighing ≥15 kg were administered a single 200 μg/kg ivermectin dose, repeated after 10-42 days if Strongyloides and/or scabies was diagnosed; others followed a standard alternative algorithm. A questionnaire on clinical symptoms was administered to identify adverse events from treatment and self-reported symptoms associated with serostatus. We surveyed 1013 participants at the baseline population census and 1060 (n = 700 from baseline cohort and 360 new entrants) at month 12. Strongyloides seroprevalence fell from 21% (175/818) at baseline to 5% at month 6...Continue Reading

References

Mar 1, 1992·Internal Medicine·K ShikiyaK Kobari
May 1, 1981·Reviews of Infectious Diseases·Y Igra-SiegmanD B Louria
May 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·A DatryM Gentilini
Jan 1, 1994·Diagnostic Microbiology and Infectious Disease·J KobayashiY Shiroma
Jan 1, 1996·Advances in Parasitology·D I Grove
Aug 31, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A A Siddiqui, S L Berk
Sep 13, 2002·The American Journal of Tropical Medicine and Hygiene·Mona R LoutfyKevin C Kain
Oct 24, 2002·International Journal for Parasitology·Mark DorrisMark L Blaxter
Sep 2, 2003·Nature Reviews. Immunology·Rick M Maizels, Maria Yazdanbakhsh
Jul 29, 2005·The Australian Journal of Rural Health·Fay H JohnstonKaren Dempsey
Jan 18, 2006·International Journal of Dermatology·Assen L DourmishevRobert A Schwartz
Mar 23, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Wendy A PageJames S McCarthy
Sep 28, 2006·PLoS Medicine·María-Gloria BasáñezMichel Boussinesq
Sep 18, 2007·Immunology and Allergy Clinics of North America·Thomas B Nutman
May 24, 2008·Public Health Nutrition·Erin McLeanBruno de Benoist
Aug 19, 2008·The Medical Journal of Australia·David A Pattison, Richard Speare
Dec 3, 2008·International Journal of Epidemiology·Theo VosAlan D Lopez
Mar 31, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Annette OlsenPascal Magnussen
Jul 7, 2009·Lancet·Malcolm KingMichael Gracey
Sep 16, 2009·PLoS Neglected Tropical Diseases·Denise MupfasoniAlan Fenwick
Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Roberto R Ricardo-GonzalezAjay Chawla
May 12, 2011·Reviews in Endocrine & Metabolic Disorders·Jeffrey T Jensen
Jul 2, 2011·Health Promotion Journal of Australia : Official Journal of Australian Association of Health Promotion Professionals·Alyssa VassYurranydjil Dhurrkay
Aug 5, 2011·PLoS Neglected Tropical Diseases·Zeno BisoffiFederico Gobbi
Oct 11, 2011·Nature Reviews. Immunology·Ajay ChawlaY P Sharon Goh
Oct 31, 2015·PLoS Neglected Tropical Diseases·Thérèse M KearnsRoss M Andrews

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Citations

Oct 14, 2018·Journal of Paediatrics and Child Health·Angela Wilson, Deborah Fearon
Nov 27, 2019·The American Journal of Tropical Medicine and Hygiene·Sammy M NjengaJeffrey W Priest
Jan 9, 2020·The American Journal of Tropical Medicine and Hygiene·Daniel L Bourque, Karin Leder
Dec 6, 2019·The American Journal of Tropical Medicine and Hygiene·Matthew PaltridgeJosh Hanson
May 19, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael MarksDiana Martin
May 19, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Valdir Sabbaga Amato, Felipe Francisco Tuon
Oct 3, 2018·Tropical Medicine and Infectious Disease·Angela Wilson, Deborah Fearon
Jun 30, 2019·Pathogens·Mae A F WhiteKirstin E Ross
Sep 6, 2020·Journal of Clinical Gastroenterology·Michael FarthingAnton Le Mair
Oct 3, 2018·Tropical Medicine and Infectious Disease·Wendy PageRichard S Bradbury
Oct 3, 2018·Tropical Medicine and Infectious Disease·Meruyert BeknazarovaKirstin Ross
Oct 3, 2018·Tropical Medicine and Infectious Disease·R C Andrew Thompson
Jan 8, 2021·BMC Infectious Diseases·Sarah HaniehUNKNOWN Child Health and Nutrition Study team
Jul 2, 2021·Tropical Diseases, Travel Medicine and Vaccines·Giulia Rinaldi, Kholoud Porter
Jul 22, 2021·Emerging Infectious Diseases·Richard S BradburyCharlotte V Hobbs
Dec 24, 2021·Internal Medicine Journal·Meruyert Cooper-BeknazarovaKirstin E Ross

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Methods Mentioned

BETA
MDA
ELISA
MDAs

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