Strongyloides stercoralis infection in marmosets: replication of complicated and uncomplicated human disease and parasite biology

Parasites & Vectors
Vitor Luís Tenório MatiAlan Lane de Melo

Abstract

Strongyloides stercoralis can undergo an alternative autoinfective life cycle in the host, which, in some individuals can lead to a lethal infection. However, due to a number of factors, such as, the majority of those infected are from low-income backgrounds and the limitation in experimental models for studying human S. stercoralis, strongyloidiasis remains neglected. Improved knowledge of animal models that are susceptible to this parasite is needed in order to investigate the immunological mechanisms involved during infection and in particular to further understand the natural history of the autoinfective cycle. Callithrix penicillata were inoculated subcutaneously with 100 (n = 2), 300 (n = 4) or 500 (n = 9) third-stage infective larvae (L3i) of S. stercoralis of human origin. Three marmosets received smaller inocula (i.e., one received 100 and two received 300 L3i) to ensure a greater capacity to withstand the infection after immunosuppression, which was triggered by administration of dexamethasone during early patency. Qualitative faecal analyses began at 7 days post-infection (DPI), and semi-quantitative tests were also performed for the dexamethasone-treated primates and the three matched controls. During the necropsies...Continue Reading

References

Jan 1, 1978·Veterinary Pathology·A DePaoli, D O Johnsen
Oct 1, 1992·Clinical Microbiology Reviews·R M Genta
Dec 1, 1992·The American Journal of Tropical Medicine and Hygiene·L S Mansfield, G A Schad
Jun 1, 1989·Journal of Helminthology·D A DenhamC M Hetherington
Jul 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·R M Genta
Dec 1, 1988·Archives of Dermatology·L C von Kuster, R M Genta
Mar 1, 1987·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·P B Nielsen, M Mojon
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·R M GentaM E Hellman
Jun 25, 1966·Lancet·A J Willis, C Nwokolo
Jan 1, 1971·Transactions of the Royal Society of Tropical Medicine and Hygiene·J L CravenM G Lewis
Nov 17, 1966·The New England Journal of Medicine·T CruzH Rocha
Feb 21, 1966·JAMA : the Journal of the American Medical Association·W A Rogers, B Nelson
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·E M CarvalhoH Rocha
Jun 1, 1984·Experimental Parasitology·G A SchadD W Muncey
May 1, 1984·The American Journal of Tropical Medicine and Hygiene·J S HarperF A Neva
May 1, 1984·The American Journal of Tropical Medicine and Hygiene·R M GentaF A Neva
Jan 1, 1982·European Journal of Immunology·L M Bradley, R I Mishell
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·D I Grove, C Northern
Jul 4, 1980·JAMA : the Journal of the American Medical Association·R A HarrisJ Clarridge
Mar 1, 1995·The American Journal of Tropical Medicine and Hygiene·L S MansfieldG A Schad
May 1, 1993·The American Journal of Tropical Medicine and Hygiene·G A SchadR Maze
Apr 1, 1996·American Journal of Respiratory Cell and Molecular Biology·F H KrouwelsT A Out
Mar 26, 1998·International Journal for Parasitology·T KinjoT Iwamasa
Jan 4, 2001·The Korean Journal of Parasitology·D N Onah, Y Nawa
Jul 4, 2001·QJM : Monthly Journal of the Association of Physicians·P R SánchezC R Olmos
Aug 31, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A A Siddiqui, S L Berk
Oct 9, 2001·Parasite Immunology·A F PortoE M Carvalho
Aug 1, 1958·A.M.A. Archives of Dermatology·R P ARTHUR, W B SHELLEY
Oct 11, 2003·Journal of Clinical Pharmacology·Donald E MagerWilliam J Jusko
Jan 17, 2004·Clinical Microbiology Reviews·Paul B Keiser, Thomas B Nutman
Aug 4, 2004·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kenji OhnishiNobuaki Akao
Aug 28, 2004·Revista Da Sociedade Brasileira De Medicina Tropical·Ana Luna de OliveiraJosé Valfrido de Santana
Jan 7, 2005·Clinical Pharmacokinetics·David CzockUlla Häussler
Feb 19, 2005·Journal of Clinical Gastroenterology·Ronald ConchaArvey I Rogers
Aug 23, 2005·Proceedings of the American Thoracic Society·Robert P Schleimer
Mar 15, 2006·The Journal of Infection·Laurence FardetJean Cabane
Jun 1, 2006·Clinical and Molecular Allergy : CMA·Raja S VadlamudiGuha Krishnaswamy
Jul 31, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·Kinjalka Ghosh, Kanjaksha Ghosh
Mar 7, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Luis A MarcosEduardo Gotuzzo
Mar 31, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Annette OlsenPascal Magnussen
Aug 26, 2009·International Journal of Dermatology·Ricardo GalimbertiAlicia Kowalczuk
Jun 3, 2011·The American Journal of Tropical Medicine and Hygiene·Eleuza R MachadoLúcia H Faccioli
Jul 30, 2011·Bulletin de la Société de pathologie exotique·J-F Pays
Mar 6, 2012·Primates; Journal of Primatology·Alan Lane de MeloWanderlany Amâncio Martins
Jun 20, 2012·Current Opinion in Virology·Ricardo Carrion, Jean L Patterson
Feb 12, 2013·BMC Infectious Diseases·Dora BuonfrateZeno Bisoffi
Apr 23, 2013·Reviews in Medical Virology·Yorifumi Satou, Masao Matsuoka
May 16, 2013·PLoS Neglected Tropical Diseases·Alejandro J KrolewieckiMarco Albonico
May 16, 2013·PLoS Neglected Tropical Diseases·Zeno BisoffiMarco Albonico
Jul 13, 2013·Frontiers in Microbiology·Yasuko Tsunetsugu-Yokota, Mahmod Muhsen
Jul 23, 2013·PLoS Neglected Tropical Diseases·Fabian SchärPeter Odermatt
Jan 1, 1982·American Journal of Primatology·J S HarperC Middleton

Methods Mentioned

BETA
scraping
bronchoalveolar lavage

Related Concepts

Autopsy
Callithrix
Cell Cycle
Dexamethasone
Feces
Laboratory
Larva
Lung Neoplasms
Parasites
Primates

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Laryngeal Neoplasms

Laryngeal Neoplasms occur in the Larynx and are typically associated with smoking and alcohol consumption. Discover the latest research on Laryngeal Neoplasms here.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.