Strontium ranelate--a promising therapeutic principle in osteoporosis

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Georges BoivinDelphine Farlay

Abstract

Strontium ranelate (2g/day) appears to be a safe and efficient treatment of osteoporosis (OP), reducing the risks of both vertebral and non-vertebral fractures (including hip) in a wide variety of patients. Thus, the agent can now be considered as a first-line option to treat women at risk of OP fractures, whatever their age and the severity of the disease. A long-term treatment with strontium ranelate in OP women leads to a continued increase in bone mineral density at spine and hip levels, and a sustained antifracture efficacy. The mode of action of strontium ranelate involves a dissociation between bone resorption and formation, as the bone formation rate is increased and not influenced by the antiresorptive action of the agent. Strontium is heterogeneously distributed in bone tissue: it is absent from old bone tissue and is exclusively present in bone formed during the treatment. Total area containing strontium in bone tissue increases during treatment, although the focal bone strontium content is constant. Whatever the duration of treatment and the content of strontium in bone, the degree of mineralization is maintained in a normal range. Furthermore, no change at crystal level is detected up to 3 years of treatment.

References

Oct 31, 2001·Calcified Tissue International·P J MarieC Rey
Aug 15, 2002·European Journal of Pharmacology·Roland Baron, Yannis Tsouderos
Jun 24, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N TakahashiT Suda
Sep 25, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Georges Boivin, Pierre J Meunier
Mar 27, 2004·Metabolism: Clinical and Experimental·A BarbaraP J Marie
Nov 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Patrick AmmannRene Rizzoli
Jun 9, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Monique ArlotErik Fink Eriksen
Aug 2, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Delphine FarlayPierre Jean Meunier
May 26, 2006·The New England Journal of Medicine·Ego Seeman, Pierre D Delmas
Jun 6, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Patrick AmmannRené Rizzoli
Dec 20, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S D BainP Ammann
Jan 21, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P J MeunierJ Y Reginster
Jul 15, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·G BoivinP J Meunier
Jan 22, 2010·Journal of Bone and Mineral Metabolism·Delphine FarlayGeorges Boivin
Sep 3, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P J MarieM L Brandi
Dec 23, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yohann BalaGeorges Boivin

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Citations

Nov 12, 2013·Micron : the International Research and Review Journal for Microscopy·André L RossiMarcos Farina
Sep 6, 2014·British Medical Bulletin·Rebecca E WalkerAndrew D Chantry
Feb 26, 2013·Seminars in Arthritis and Rheumatism·Eveline BoudinWim Van Hul
Apr 21, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Amélie I S SobczakAlan J Stewart
Dec 18, 2013·Biomedical Materials·Grégory ChatelainDaniel Meyer
Sep 22, 2020·Journal of Biomaterials Applications·Yaichiro OkuzuShuichi Matsuda
Jun 25, 2014·Bulletin of Experimental Biology and Medicine·I A KhlusovV V Novitskii
Jan 30, 2020·Journal of Periodontology·Tamires Szeremeske MirandaPoliana Mendes Duarte

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