Strontium Sulfite: A New pH-Responsive Inorganic Nanocarrier to Deliver Therapeutic siRNAs to Cancer Cells

Pharmaceutics
Md Emranul KarimEzharul Hoque Chowdhury

Abstract

Inorganic nanoparticles hold great potential in the area of precision medicine, particularly for treating cancer owing to their unique physicochemical properties, biocompatibility and improved pharmacokinetics properties compared to their organic counterparts. Here we introduce strontium sulfite nanoparticles as new pH-responsive inorganic nanocarriers for efficient transport of siRNAs into breast cancer cells. We employed the simplest nanoprecipitation method to generate the strontium sulfite nanoparticles (SSNs) and demonstrated the dramatic roles of NaCl and d-glucose in particle growth stabilization in order to produce even smaller nanosize particles (Na-Glc-SSN) with high affinity towards negatively charged siRNA, enabling it to efficiently enter the cancer cells. Moreover, the nanoparticles were found to be degraded with a small drop in pH, suggesting their potential capability to undergo rapid dissolution at endosomal pH so as to release the payload. While these particles were found to be nontoxic to the cells, they showed higher potency in facilitating cancer cell death through intracellular delivery and release of oncogene-specific siRNAs targeting ros1 and egfr1 mRNA transcripts, than the strontium sulfite particles p...Continue Reading

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Citations

Feb 4, 2021·Biomedicines·Sulltana JahanEzharul Hoque Chowdhury
Sep 8, 2021·Journal of Biomaterials Science. Polymer Edition·Yifan HuangBinjie Xin

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Methods Mentioned

BETA
X-ray
Assay
De
scanning electron microscopy
infrared spectroscopy

Software Mentioned

Varian Resolution Pro
Elmer 2030 manager
Agilent MassHunter
Zetasizer
PEAKS
SPSS
Perkin
PEAKS Studio
Perkin 2030 manager
PEAKS Q

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