PMID: 3767525Jul 1, 1986Paper

Strontium uptake during the different modes of contraction in the smooth muscle of rabbit aorta, rat aorta and guinea-pig taenia coli

Archives Internationales De Pharmacodynamie Et De Thérapie
H KarakiN Urakawa

Abstract

Effects of Sr substitution for Ca on the contractions due to Ca influx in the aortae of rabbit and rat and the guinea-pig taenia coli were examined in order to characterize the pathways of Ca influx activated by either high K or receptor agonists. In normal solution containing Ca, high K increased both muscle tension and 45Ca uptake in rabbit and rat aortae and guinea-pig taenia. In Sr-substituted solution, high K also induced contractions accompanied by the increases in 89Sr uptake. Noradrenaline induced sustained contraction and increase in 45Ca uptake in normal solution whereas it induced only small contraction accompanied by small increase in 89Sr uptake in Sr-substituted solution in the aortae. Histamine increased neither muscle tension nor 89Sr uptake in Sr-substituted solution although it increased muscle tension as well as 45Ca uptake in normal solution in taenia. Ca and Sr both induced contraction in saponin-treated smooth muscles. The concentration of Sr to induce half maximum contraction was approximately 20 times higher than that for Ca in rabbit and rat aortae or 62 times higher in guinea-pig taenia. From these results, it is suggested that Ca and Sr enter the smooth muscle cells through K-activated channels and in...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.