Structural abnormalities detected by knee magnetic resonance imaging are common in middle-aged subjects with and without risk factors for osteoarthritis

Acta Orthopaedica
Jaanika KummMartin Englund

Abstract

Background and purpose - Few data are available regarding structural changes present in knees without radiographically evident osteoarthritis (OA). We evaluated the prevalence of findings suggestive of knee OA by magnetic resonance imaging (MRI) in middle-aged subjects without radiographic OA with or without OA risk factors. Patients and methods - 340 subjects from the Osteoarthritis Initiative, aged 45-55 years (51% women) with Kellgren-Lawrence grade 0 in both knees, who had 3T knee MR images were eligible. 294 subjects had risk factors and 46 were without risk factors. MR images were assessed using the MOAKS scoring system. Results - At least 1 MR-detected feature was found in 96% (283/294) of subjects with risk factors and in 87% (40/46) of those without. Cartilage damage (82%), bone marrow lesions (60%), osteophytes (45%), meniscal body extrusion (32%), and synovitis-effusion (29%) were the most common findings in subjects with risk factors, while cartilage damage (67%), osteophytes (46%), meniscal body extrusion (37%), and bone marrow lesions (35%) were most common in subjects without. The prevalence of any abnormality was higher in subjects with OA risk factors than in subjects without (prevalence ratio adjusted for age ...Continue Reading

References

Apr 3, 2001·Annals of Internal Medicine·D T FelsonD R Gale
Sep 21, 2006·AJR. American Journal of Roentgenology·Arthur A De Smet, Michael J Tuite
Aug 5, 2008·Annals of the Rheumatic Diseases·M L Davies-TuckF Cicuttini
Sep 12, 2008·The New England Journal of Medicine·Martin EnglundDavid T Felson
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Sep 11, 2010·Annals of the Rheumatic Diseases·Erlangga YusufMargreet Kloppenburg
May 31, 2011·Osteoarthritis and Cartilage·D J HunterUNKNOWN OARSI OA Imaging Working Group

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