PMID: 9431852Feb 12, 1998Paper

Structural adaptation to ischemia in skeletal muscle: effects of blockers of the renin-angiotensin system

Journal of Hypertension
K J ScheideggerJ M Wood

Abstract

To investigate the effects of long-term treatment with blockers of the renin-angiotensin system on capillarization and growth of fibers in ischemic hind-limb muscles and in muscles under normal growth conditions. Ischemia was induced by partial ligation of the left common iliac artery. Ischemia resulted in a significant increase in capillary and fiber density in the soleus muscle, a significant decrease in mean fiber size and a decrease in muscle cross-sectional area after 4 weeks compared with the contralateral nonischemic muscle. Ischemia also significantly decreased the muscle: body weight ratio of the left soleus muscle. We observed no significant effect on total number of capillaries and capillary: fiber ratio, suggesting that ischemia did not result in an increase in capillarization in this muscle. Treatments with subhypotensive and with hypotensive doses of the angiotensin converting enzyme (ACE) inhibitor benazeprilat, the angiotensin (Ang) II AT1 antagonist valsartan, or the Ang II AT2 antagonist PD 123 319 for 4 weeks did not influence any of the above-described changes in the normal and ischemic muscles and treatment effects were also independent of the degree of reduction of blood pressure. Treatments with an ACE in...Continue Reading

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Citations

Mar 31, 2005·Molecular and Cellular Biology·Zhong YunAmato J Giaccia
Jan 6, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Bo ZhangKeijiro Saku
May 24, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Qi GuoMasahiro Kohzuki
Feb 7, 2016·The Journal of Surgical Research·Matthew A ZieglerJoseph L Unthank

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