PMID: 8609149Jan 1, 1996Paper

Structural alterations in the transcription factor PEBP2/CBF linked to four different types of leukemia

Journal of Cancer Research and Clinical Oncology
Y Ito

Abstract

Polyomavirus enhancer binding protein 2 (PEBP2), also called core binding factor (CBF), is a heterodimer composed of the alpha and the beta subunits. Structural alterations of each of the two subunits generated by recurrent chromosome translocations/inversion are associated with acute myeloid leukemia or acute lymphoblastic leukemia. Chimeric proteins containing a part of either the alpha or beta subunits have a potential to affect the transcriptional regulation through the PEBP2/CBF site. Structure and function of PEBP2/CBF and possible mechanisms of leukemogenesis caused by the chimeric proteins are summarized.

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Citations

Apr 30, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J M SchmittJ O Hollinger
Jan 5, 2000·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Y Ito
Oct 28, 2004·Journal of Virology·Yu TianThomas Benjamin
Aug 28, 1998·Leukemia & Lymphoma·N AsouK Takatsuki
Sep 24, 2015·PloS One·Chih-Hao HsuSoheil Meshinchi
May 23, 1998·Journal of Molecular Biology·D LevanonY Groner
Apr 30, 2005·Journal of Cellular Biochemistry·Malgorzata Gasperowicz, Florian Otto
Jun 7, 1997·Biochimica Et Biophysica Acta·L Wolff

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