Structural analysis and immunoregulation activity comparison of five polysaccharides from Angelica sinensis

Carbohydrate Polymers
Junmin WangFeifei Li

Abstract

Four fractional polysaccharides (CAPS30, CAPS50, CAPS70 and CAPS80) and total polysaccharides (CAPSt) were obtained from Angelica sinensis. Their structures were identified by Fourier transform-infrared spectroscopy (FT-IR), molecular weights were evaluated by high performance gel permeation chromatography (HPGPC) and compositions were analyzed by gas chromatography-mass spectrometry (GC-MS). Their immunoregulation activities were further compared in vitro. The results showed that they displayed different structural features and immuno-enhancement activities. They all could cause the proliferation of the lymphocyte, up-regulate stimulate the productions of IFN-γ, IL-2, IL-6 and TNF-α secretion in the peripheral lymphocytes. Further experiments showed that CAPS50 and CAPS70 could increase the ratio of CD3(+)CD56(+) cells to some extent. These indicated that five CAPSs displayed different activities which were associated with their different structural characteristics and CAPS70, with the molecular weights of 20.82kDa and consisting of mannose and glucose in the molar ratio of 1.20:1.01, possessed the strongest immuno-enhancement activity.

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Citations

Dec 17, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yun ChenJiaguo Liu
Feb 23, 2019·International Journal of Immunopathology and Pharmacology·Jun WangChengfei Guan
Feb 24, 2021·International Journal of Biological Macromolecules·Adelijiang WusimanDeyun Wang
Mar 23, 2021·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Tomás G VillaCarmen Sieiro
Jun 7, 2021·International Journal of Biological Macromolecules·Jijuan NaiHuagang Sheng
Jul 4, 2021·Progress in Biophysics and Molecular Biology·Tianmei LiRongji Dai
Jul 1, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hui Pan, Linlin Zhu
Nov 23, 2018·International Journal of Biological Macromolecules·Chao TangNianfeng Zhang

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