Structural analysis of Heschl's gyrus in schizophrenia patients with auditory hallucinations

Neuropsychobiology
Daniela HublThomas Koenig

Abstract

Heschl's gyrus (HG) is functionally involved in the genesis of auditory verbal hallucinations (AVH). This dysfunction seems to be structurally facilitated. The aim of the study was to analyze macrostructural features of HG in a group of patients reporting AVH who demonstrated white matter diffusion tensor imaging abnormalities reported previously. 3-D anatomical MR scans were obtained (patients with and without history of AVH, controls). HG was delineated by manual segmentation. Cortical folding, absolute and relative volumes, laterality were analyzed. According to the literature, in the collapsed group of patients, the normal left-greater-than-right laterality of HG was attenuated. We found a trend towards a higher number of duplicated HG in hallucinating patients. We also found a bigger volume of HG in the right hemisphere in hallucinating patients. This effect was caused by gray and white matter increase. This is the first study on manual volumetry of HG in a group of schizophrenia patients with AVH compared to patients without AVH. In a previous analysis of the diffusion tensor imaging data of the here presented sample, we found higher directionality of the arcuate fasciculus in patients with AVH, facilitating abnormal co-a...Continue Reading

Citations

Oct 27, 2010·Current Opinion in Neurology·Johanna C GollJason D Warren
May 28, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Katherine R HenshallDavid L Copolov
Apr 14, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Inga Griskova-BulanovaThomas Koenig
Mar 1, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Gemma ModinosPaul Allen
Sep 21, 2010·Schizophrenia Research·C Christoph SchultzRalf G M Schlösser
Apr 27, 2010·Psychiatry Research·Helge HornWerner Strik
Dec 15, 2015·Acta Psychiatrica Scandinavica·R UpthegroveS J Wood
May 10, 2015·Neuroscience and Biobehavioral Reviews·Ben Alderson-DayCharles Fernyhough
Sep 10, 2013·Schizophrenia Research·J Tilak RatnanatherPatrick E Barta
Feb 22, 2012·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Katherine R HenshallDavid L Copolov
Dec 7, 2013·Brain Structure & Function·D MarieN Tzourio-Mazoyer
Sep 9, 2016·Schizophrenia Bulletin·Lynn Mørch-JohnsenIngrid Agartz
Sep 15, 2010·Biological Psychology·Derek J FisherVerner J Knott
Apr 27, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Viola Oertel-Knöchel, David E J Linden
May 22, 2010·Current Opinion in Neurology·Jean-François ManginArnaud Cachia
Jan 16, 2021·Journal of Personalized Medicine·Tsutomu TakahashiMichio Suzuki
May 8, 2021·Frontiers in Behavioral Neuroscience·Tsutomu TakahashiMichio Suzuki

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