PMID: 2489070Apr 1, 1989Paper

Structural analysis of homologous repeated domains in alpha-actinin and spectrin

International Journal of Biological Macromolecules
M D DavisonJ C Wootton

Abstract

The amino acid sequences of chick and slime mould alpha-actinin each contain four repeats of approximately 122 residues. These repeats are homologous to the 18-22 repeats, each of approximately 106 residues, found in the alpha and beta subunits of spectrin and fodrin, and to the multiple repeats of approximately 110 residues found in the Duchenne muscular dystrophy protein (dystrophin). The repeats correspond to the elongated rod-like portion of these molecules. We present a multiple sequence alignment of 21 repeats from this superfamily (8 alpha-actinin and 13 spectrin/fodrin), based on optimal pairwise alignments, from which a characteristic consensus pattern of amino acid types is deduced. Trp 46 is invariant in all but one repeat, and physicochemical classes of amino acids are conserved at 25 other positions. Secondary structure prediction on both the alpha-actinin and spectrin repeats taken together with the distribution of proline residues in the sequences, strongly suggest that each repeated domain consists of a four-helix structure. Our predictions differ significantly from previous three-helix models based on analyses of fewer sequences. To determine possible interdomain regions, sites of limited proteolysis of the nat...Continue Reading

References

Jan 1, 1979·The Journal of Cell Biology·S W Craig, J V Pardo
Dec 15, 1977·Nature·B M JockuschG Gabbiani
Sep 15, 1977·Journal of Molecular Biology·M J Dufton, R C Hider
Sep 26, 1978·Biochimica Et Biophysica Acta·D ShottonD Branton
Mar 28, 1977·Biochimica Et Biophysica Acta·I SinghM H Stromer
Feb 25, 1975·Journal of Molecular Biology·Z A PodlubnayaG A Stefanenko
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·R G PartonD R Critchley
Mar 1, 1988·Cellular and Molecular Neurobiology·S H SnyderJ M Baraban
Dec 2, 1985·European Journal of Biochemistry·F LandonA Olomucki
Dec 12, 1986·Biochimica Et Biophysica Acta·A MalhotraH S Slayter
Mar 22, 1985·Science·D J Lipman, W R Pearson
Jan 1, 1987·Differentiation; Research in Biological Diversity·A P McMahonR T Moon
Jan 29, 1988·Cell·M D Davison, D R Critchley
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J T PrchalY W Kan
Aug 31, 1987·FEBS Letters·V M WaseniusM Saraste
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C S BirkenmeierJ E Barker
Jan 25, 1973·Biochimica Et Biophysica Acta·R M Robson, M G Zeece
Jan 15, 1974·Biochemistry·P Y Chou, G D Fasman
Nov 1, 1982·The Journal of Cell Biology·K BurridgeP Mangeat
Sep 4, 1980·Nature·P C Weber, F R Salemme
Nov 2, 1984·European Journal of Biochemistry·J R Glenney, P Glenney
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J S MorrowV T Marchesi
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S R GoodmanR R Kulikowski
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D W SpeicherV T Marchesi

❮ Previous
Next ❯

Citations

Jan 1, 1990·The International Journal of Biochemistry·M J Saxton
Jan 1, 1995·Brain Research Bulletin·S R GoodmanM L Bloom
Sep 1, 1994·Neuromuscular Disorders : NMD·N J WinandB J Cooper
Nov 6, 1998·Molecular and Biochemical Parasitology·G BricheuxG Brugerolle
Oct 26, 2002·Brain Research. Molecular Brain Research·Elena V Leonova, Margaret I Lomax
Apr 1, 1993·Nature Genetics·A H Ahn, L M Kunkel
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A S Harris, J S Morrow
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·E WinogradD Branton
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T J ByersD Branton
Aug 1, 1990·The Journal of Cell Biology·C A OteyK Burridge
Nov 1, 1990·The Journal of Cell Biology·R R DubreuilD P Kiehart
Jun 17, 2003·Molecular Biology of the Cell·Lisa Lucio GoughKenneth A Beck
Oct 1, 1994·European Journal of Biochemistry·A P GilmoreD R Critchley
May 1, 1991·The Journal of Clinical Investigation·V Bennett, S Lambert
May 27, 2010·PLoS Genetics·Glen B BanksJeffrey S Chamberlain
Apr 14, 1992·Biochemistry·D M BudzynskiL W Fung
May 18, 1993·Biochemistry·C J WallisE F Wenegieme
Mar 12, 1990·FEBS Letters·R A CrossJ Kendrick-Jones
Jan 1, 1994·Cell Motility and the Cytoskeleton·N K Subbarao, R C MacDonald
May 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R R Dubreuil
Jan 15, 1995·European Journal of Biochemistry·G TravéM Saraste
Apr 29, 2011·Biophysics·You Jia, Masaaki Kuroda
Aug 1, 1989·Journal of Muscle Research and Cell Motility·A BlanchardD Critchley
Dec 16, 2011·Oncotarget·Luca D'Agostino, Antonio Giordano
Mar 16, 1994·Biochimica Et Biophysica Acta·M KurodaM Sasaki
Apr 13, 1994·Biochimica Et Biophysica Acta·E F WenegiemeA P Naren
Mar 1, 1991·Trends in Biochemical Sciences·P Matsudaira
Oct 1, 1989·Trends in Biochemical Sciences·A P Monaco
Jan 1, 1994·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·E BaumannW Richter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved