Structural Analysis of Recent Allergen-Antibody Complexes and Future Directions

Current Allergy and Asthma Reports
Geoffrey A MuellerLars C Pedersen

Abstract

Allergen-antibody complexes are extremely valuable in describing the detailed molecular features of epitopes. This review summarizes insights gained from recently published co-structures and what obstacles impede the acquisition of further data. Structural epitope data helped define the epitopes of two anti-Fel d 1 antibodies undergoing phase I clinical trials, providing a greater level of detail than was possible through hydrogen-deuterium exchange protection studies. Separately, a human camelid-like antibody structure with lysozyme described several unique features in a long variable loop that interacted with the active site cleft of Gal d 4. Finally, a co-structure conclusively demonstrated that Phl p 7 could function as a superantigen and that an antibody could simultaneously recognize two epitopes. These remarkable assertions would not have been possible without visualization of the complex. Only three new complexes have appeared in the last few years, suggesting that there are major impediments to traditional production and crystallization. The structural data was extremely valuable in describing epitopes. New techniques like cryo-EM may provide an alternative to crystallography.

References

Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E A PadlanD R Davies
Dec 15, 1994·Structure·O PerisicR L Williams
Jun 3, 1993·Nature·C Hamers-CastermanR Hamers
Jan 29, 2000·Journal of Immunological Methods·L Riechmann, S Muyldermans
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·O MirzaM Gajhede
Sep 5, 2002·European Journal of Immunology·Sabine FlickerRudolf Valenta
Oct 14, 2003·International Archives of Allergy and Immunology·Liselotte KaiserMarianne van Hage-Hamsten
Jul 9, 2004·Current Opinion in Allergy and Clinical Immunology·Petra A Wachholz, Stephen R Durham
Jan 22, 2005·The Journal of Biological Chemistry·Erwin De GenstSerge Muyldermans
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Erwin De GenstLode Wyns
Aug 8, 2007·Journal of Molecular Biology·Evgeny Krissinel, Kim Henrick
Aug 19, 2007·Current Allergy and Asthma Reports·Martin D ChapmanAnna Pomés
Jun 4, 2008·The Journal of Biological Chemistry·Mi LiAnna Pomés
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sivaraman PadavattanZora Markovic-Housley
Feb 19, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R C AalberseT Rispens
Apr 13, 2010·The Journal of Allergy and Clinical Immunology·Christopher L Karp
Dec 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mi LiAlexander Wlodawer
Feb 2, 2011·The Journal of Allergy and Clinical Immunology·Louisa K JamesStephen R Durham
Jan 3, 2012·The Journal of Biological Chemistry·Maksymilian ChruszczMartin D Chapman
Oct 16, 2012·The Journal of Allergy and Clinical Immunology·Eva-Maria VargaMohamed H Shamji
Jan 22, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W R Thomas
Mar 19, 2013·Annual Review of Biochemistry·Serge Muyldermans
Mar 19, 2013·Molecular Immunology·LeAnna N WillisonKenneth H Roux
Jul 31, 2013·Methods : a Companion to Methods in Enzymology·Fabio Dall'antoniaWalter Keller
Aug 3, 2013·Frontiers in Immunology·André FrenzelThomas Schirrmann
Mar 29, 2014·Molecular Immunology·Geoffrey A MuellerRobert E London
Jun 19, 2014·The Journal of Biological Chemistry·Debajyoti GhoshSwati Gupta Bhattacharya
Dec 24, 2014·Nature Reviews. Rheumatology·William H Robinson
Mar 5, 2015·The Journal of Biological Chemistry·Romain RouetDaniel Christ
Mar 10, 2015·Current Allergy and Asthma Reports·Anna PomésAlexander Wlodawer
May 2, 2015·The Journal of Allergy and Clinical Immunology·Geoffrey A MuellerAnna Pomés
May 20, 2015·The Journal of Allergy and Clinical Immunology·Sarita U PatilWayne G Shreffler
May 31, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomasz OsinskiMaksymilian Chruszcz
Jul 7, 2015·The Journal of Allergy and Clinical Immunology·Anna PomésMartin D Chapman

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Citations

Sep 27, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jill GlesnerAnna Pomés
Jul 29, 2020·Protein Engineering, Design & Selection : PEDS·Monica L Fernández-QuinteroKlaus R Liedl
Jan 7, 2021·Analytical and Bioanalytical Chemistry·Haofeng SunDewei Song
Apr 19, 2021·Allergy·Maksymilian ChruszczHeimo Breiteneder
Jun 15, 2021·The Journal of Allergy and Clinical Immunology·Amanda AtanasioJamie M Orengo

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