PMID: 11929857Apr 4, 2002Paper

Structural analysis of the chicken BRCA2 gene facilitates identification of functional domains and disease causing mutations

Human Molecular Genetics
Madhuri WarrenA Ashworth

Abstract

Carriers of mutations in the BRCA2 gene have a high risk of developing breast and other cancers. The BRCA2 gene, which is located on human chromosome 13, encodes a very large protein of only poorly understood function. To define regions of sequence conservation and highlight potentially functionally important domains, we have cloned and characterized the chicken BRCA2 gene, the first non-mammalian BRCA2 gene to be described. The gene is organized similarly to the human BRCA2 gene, but is more compact and is localized to the subtelomeric region of chicken chromosome 1q, within a region that contains other genes from human chromosome 13. The chicken BRCA2 gene encodes a protein of 3399 amino acids, which is poorly conserved with mammalian BRCA2 proteins, having only 37% amino acid identity overall with human BRCA2. However, certain domains are much more highly conserved, indicating functional significance. We describe genes with some of these conserved domains in organisms as diverse as intracellular parasites, mosquitoes and plants. The evolutionarily divergent chicken BRCA2 sequence may also be useful in assigning the large number of sequence variants that have been described in the human BRCA2 gene which are of unknown signifi...Continue Reading

Citations

Nov 13, 2002·Mutation Research·Larry H Thompson, David Schild
Dec 10, 2002·Trends in Molecular Medicine·Andrew Tutt, Alan Ashworth
Nov 21, 2002·Nature·Luca PellegriniAshok R Venkitaraman
Jul 7, 2011·Nature Structural & Molecular Biology·William K Holloman
May 21, 2005·Cytogenetic and Genome Research·M SchmidS Mizuno
May 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi SaekiMaria Jasin
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Silvia de SanjoséOlga M Sinilnikova
Aug 30, 2008·International Journal for Parasitology·Samuel O OyolaSara E Melville
Dec 21, 2010·Molecular Microbiology·Milorad KojicWilliam K Holloman
Nov 15, 2011·The New Phytologist·Katharina SeeligerHolger Puchta
Aug 17, 2004·Trends in Cell Biology·Katrin Gudmundsdottir, Alan Ashworth
Jun 3, 2004·Cancer Genetics and Cytogenetics·Andreas HadjisavvasKyriacos Kyriacou
Jul 29, 2004·DNA Repair·Mahmud K K Shivji, Ashok R Venkitaraman
Oct 29, 2003·Molecular Cell·David S YuAshok R Venkitaraman
Dec 3, 2014·European Journal of Medicinal Chemistry·Ana P GuimarãesTanos C C França
Jul 6, 2014·European Journal of Medicinal Chemistry·Juliana O S GiacoppoTeodorico C Ramalho
Sep 16, 2016·Frontiers in Genetics·Elena MogilyanskyIsidore Rigoutsos
Jan 18, 2016·Carcinogenesis·Tryggvi ThorgeirssonUNKNOWN Transdisciplinary Prostate Cancer Partnership (ToPCaP)
Nov 6, 2003·The Journal of Veterinary Medical Science·Toshina OonumaBunei Syuto
Aug 24, 2005·Médecine sciences : M/S·Dora Papadopoulo, Ethel Moustacchi
Nov 14, 2021·Proceedings of the National Academy of Sciences of the United States of America·Laurens H LindenburgFlorian Hollfelder

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.