Structural analysis of the dur loci in S. cerevisiae: two domains of a single multifunctional gene.

Genetics
T G CooperV Turoscy

Abstract

In Saccharomyces cerevisiae, the degradation of urea to carbon dioxide and ammonia is catalyzed by urea carboxylase and allophanate hydrolase. The loci coding for these enzymes (dur1 and dur2) are very tightly linked on the right arm of chromosome II between pet11 and met8. Pleiotropic mutations that fail to complement mutations in either of the dur loci were found to be predominantly located in or near the dur2 locus. We interpret these data as suggesting that the two dur loci might in reality be domains of a single gene that codes for a multifunctional polypeptide. In view of this conclusion, we have renamed the dur loci as the dur1,2 locus.

Citations

Jun 14, 2008·Journal of Molecular Biology·Gorm AndersenJure Piskur
Aug 1, 1982·Biochemical Genetics·E M Mackay, J A Pateman
Dec 1, 1980·Microbiological Reviews·R K Mortimer, D Schild
Sep 1, 1985·Microbiological Reviews·R K Mortimer, D Schild
Dec 1, 1984·Molecular and Cellular Biology·A P Mitchell, B Magasanik
Jul 1, 1982·Molecular and Cellular Biology·R A SumradaT G Cooper
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Mar 31, 2011·BMC Evolutionary Biology·Pooja K StropeEtsuko N Moriyama

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