PMID: 7536710Jan 1, 1995Paper

Structural analysis of the RH-like blood group gene products in nonhuman primates

Immunogenetics
I SalvignolA Blancher

Abstract

Rh-related transcripts present in bone marrow samples from several species of nonhuman primates (chimpanzee, gorilla, gibbon, crab-eating macaque) have been amplified by RT-polymerase chain reaction using primers deduced from the sequence of human RH genes. Nucleotide sequence analysis of the nonhuman transcripts revealed a high degree of similarity to human blood group Rh sequences, suggesting a great conservation of the RH genes throughout evolution. Full-length transcripts, potentially encoding 417 amino acid long proteins homologous to Rh polypeptides, were characterized, as well as mRNA isoforms which harbored nucleotide deletions or insertions and potentially encode truncated proteins. Proteins of 30-40,000 M(r), immunologically related to human Rh proteins, were detected by western blot analysis with antipeptide antibodies, indicating that Rh-like transcripts are translated into membrane proteins. Comparison of human and nonhuman protein sequences was pivotal in clarifying the molecular basis of the blood group C/c polymorphism, showing that only the Pro103Ser substitution was correlated with C/c polymorphism. In addition, it was shown that a proline residue at position 102 was critical in the expression of C and c epito...Continue Reading

Citations

Jun 1, 1996·Journal of Molecular Evolution·C M Westhoff, D E Wylie
Jun 18, 2005·Blood Reviews·Caroline Le Van KimJean-Pierre Cartron
Apr 27, 2000·Transfusion Medicine Reviews·A BlancherW W Socha
Aug 14, 2001·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·J P Cartron, Y Colin
Aug 26, 2003·Legal Medicine·Hiroshi Okuda, Eiji Kajii
Dec 1, 1995·Journal of Medical Primatology·W W SochaJ Moor-Jankowski
Aug 26, 1998·Biochemical and Biophysical Research Communications·T KitanoN Saitou
May 31, 2001·British Journal of Haematology·F Noizat-PirenneJ P Cartron
Feb 13, 2001·Transfusion·J S Smythe, D J Anstee
Sep 12, 2001·Transfusion·B H FaasC E van der Schoot
Jun 27, 2002·Transfusion·Martine G H M TaxPetra A Maaskant-vanWijk
Feb 14, 2016·Genome Biology and Evolution·Takashi KitanoNaruya Saitou
May 21, 2003·Animal Genetics·T OmiS Neuenschwander
Sep 28, 2006·Transfusion·Gail CoghlanTeresa Zelinski
Jan 1, 1996·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·A BlancherJ Ruffié
Feb 13, 2001·Molecular Phylogenetics and Evolution·P Gagneux, A Varki
Sep 24, 1999·Biochemical and Biophysical Research Communications·H OkudaE Kajii
Mar 11, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A R SutinA Terracciano
Feb 10, 2000·Molecular Biology and Evolution·P A Apoil, A Blancher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.