Structural and advanced imaging in predicting MGMT promoter methylation of primary glioblastoma: a region of interest based analysis

BMC Cancer
Yu HanGuang-Bin Cui

Abstract

The methylation status of oxygen 6-methylguanine-DNA methyltransferase (MGMT) promoter has been associated with treatment response in glioblastoma(GBM). Using pre-operative MRI techniques to predict MGMT promoter methylation status remains inconclusive. In this study, we investigated the value of features from structural and advanced imagings in predicting the methylation of MGMT promoter in primary glioblastoma patients. Ninety-two pathologically confirmed primary glioblastoma patients underwent preoperative structural MR imagings and the efficacy of structural image features were qualitatively analyzed using Fisher's exact test. In addition, 77 of the 92 patients underwent additional advanced MRI scans including diffusion-weighted (DWI) and 3-diminsional pseudo-continuous arterial spin labeling (3D pCASL) imaging. Apparent diffusion coefficient (ADC) and relative cerebral blood flow (rCBF) values within the manually drawn region-of-interest (ROI) were calculated and compared using independent sample t test for their efficacies in predicting MGMT promoter methylation. Receiver operating characteristic curve (ROC) analysis was used to investigate the predicting efficacy with the area under the curve (AUC) and cross validations....Continue Reading

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Citations

Apr 27, 2018·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Whitney B Pope, Garth Brandal
Jan 10, 2019·Journal of Magnetic Resonance Imaging : JMRI·Yang YangGuang-Bin Cui
Jan 24, 2019·Neurosurgical Review·Tokunori KanazawaHikaru Sasaki
Mar 3, 2020·Expert Review of Anticancer Therapy·Asgeir Store JakolaOle Solheim
Jul 21, 2020·Journal of Neuropathology and Experimental Neurology·Vilde Elisabeth MikkelsenSverre Helge Torp
Aug 21, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Ziren KongWenbin Ma
Nov 2, 2019·British Journal of Cancer·Juliana Müller BarkChamindie Punyadeera
Jun 30, 2019·Acta neurochirurgica·Christian HenkerJürgen Piek
Nov 21, 2019·Scientific Reports·Ling-Wei KongShou-Wei Li
Oct 9, 2020·BioMed Research International·Xin ChenXinqing Jiang
Jan 8, 2021·Neurosurgical Review·Gilles ReuterEric Suero Molina
May 1, 2021·Radiologic Clinics of North America·Chaitra Badve, Sangam Kanekar
Apr 30, 2021·Neurosurgery·Birra TahaClark C Chen
Jan 19, 2022·British Journal of Neurosurgery·Mohammad AshrafAthanasios Grivas

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