Structural and analytical comparison of gallbladder stones collected from a single patient: studies of five cases

Medical Electron Microscopy : Official Journal of the Clinical Electron Microscopy Society of Japan
Tetsuo KodakaRyoichi Mori

Abstract

We observed the gross and fine structure of gallbladder stones collected from five adult patients (cases I-V) by optical photography, radiography, scanning electron microscopy, and backscattered electron microscopy, and then measured the components by energy-dispersive X-ray microanalysis and infrared spectroscopy. From the stones, calcium (Ca) phosphate, Ca bilirubinate, and Ca palmitate or fatty acid Ca were identified. The 3 cholesterol stones (case I) and the 2 brown pigment stones (case II) showed macroscopic homogeneity, respectively. In addition, their fine structure and components were also similar to each other. The black pigment stones (case III) showed macroscopic homogeneity, but they were divided into radiopaque (approximately 30 stones) and radiolucent types (approximately 60 stones). The former had Ca phosphate in the center surrounded with Ca bilirubinate, and the latter was dotted with minute deposits of Ca bilirubinate. The 6 cholesterol stones (case IV) were divided into two types in size. The 5 large stones, of macroscopic homogeneity, had a core region of Ca palmitate and clear concentric rings of Ca phosphate, whereas the smaller stone was almost filled with Ca phosphate deposits in the center. From the di...Continue Reading

Citations

Dec 12, 2012·Ultrastructural Pathology·Jose Aguilar-RuizMiguel Arrabal-Martin
Jan 6, 2009·Applied Optics·Vivek K SinghJagdish P Singh

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