Structural and biomechanical characteristics of the diaphragmatic tendon in infancy and childhood: an initial analysis

Journal of Pediatric Surgery
Shaun A SteigmanDario O Fauza

Abstract

Engineered tendon grafts have been shown, experimentally, to be promising alternatives for partial diaphragmatic replacement. This study was aimed at determining the cellularity, extracellular matrix composition, and biomechanical characteristics of the diaphragmatic tendon in infants and children to be used as a reference for proper diaphragmatic graft engineering. The left diaphragmatic tendon was procured at autopsy from 13 patients divided into 2 groups. Group I (n = 9) consisted of newborns and infants. Group II (n = 4) consisted of children and adolescents. Samples underwent quantitative assays for total DNA, glycosaminoglycans, collagen, and elastin contents. Biomechanical measurements included modular and ultimate tensile strength analyses. Statistical comparisons were by the 2-sample Student's t test. Group I showed significantly higher levels of total DNA, glycosaminoglycans, collagen, and elastin than group II. Conversely, group II tended to have higher modular and ultimate tensile strengths. In neonates and infants, the diaphragmatic tendon has increased cell density and higher levels of major extracellular matrix components than in older children, in whom the diaphragmatic tendon tends to have higher tensile streng...Continue Reading

References

Nov 11, 1992·Annals of Surgery·K P LallyJ B Atkinson
Oct 1, 1988·Analytical Biochemistry·Y J KimA J Grodzinsky
Feb 1, 1994·Journal of Pediatric Surgery·D P LundJ M Wilson
Jun 9, 2004·Journal of Pediatric Surgery·Julie R FuchsDario O Fauza
Jan 18, 2006·Journal of Pediatric Surgery·Erich J GrethelKerilyn K Nobuhara
Jun 15, 2007·Journal of Pediatric Surgery·Shaun M KunisakiDario O Fauza
Feb 19, 2008·Journal of Pediatric Surgery·Jason C FisherCharles J H Stolar
Jun 19, 2008·Journal of Pediatric Surgery·Shaun A SteigmanDario O Fauza

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Citations

Jul 6, 2014·Seminars in Pediatric Surgery·Dario O Fauza
Apr 5, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Heath B HenningerJeffrey A Weiss
May 21, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Katrien M BrouwerToin H van Kuppevelt
Jul 25, 2019·Scientific Reports·Turney J McKeeSvetlana V Komarova
Sep 21, 2017·Stem Cells International·G P LiaoY Li

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