Structural and energetic basis of allostery.

Annual Review of Biophysics
Vincent J HilserHesam N Motlagh

Abstract

Allostery is a biological phenomenon of fundamental importance in regulation and signaling, and efforts to understand this process have led to the development of numerous models. In spite of individual successes in understanding the structural determinants of allostery in well-documented systems, much less success has been achieved in identifying a set of quantitative and transferable ground rules that provide an understanding of how allostery works. Are there organizing principles that allow us to relate structurally different proteins, or are the determinants of allostery unique to each system? Using an ensemble-based model, we show that allosteric phenomena can be formulated in terms of conformational free energies of the cooperative elements in a protein and the coupling interactions between them. Interestingly, the resulting allosteric ground rules provide a framework to reconcile observations that challenge purely structural models of site-to-site coupling, including (a) allostery in the absence of pathways of structural distortions, (b) allostery in the absence of any structural change, and (c) the ability of allosteric ligands to act as agonists under some circumstances and antagonists under others. The ensemble view of...Continue Reading

References

Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R L Baldwin
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·F R Smith, G K Ackers
Jan 1, 1984·European Biophysics Journal : EBJ·A Cooper, D T Dryden
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A W Lee, M Karplus
May 1, 1997·Breast Cancer Research and Treatment·B S KatzenellenbogenE M McInerney
Nov 14, 1997·Journal of Women's Health·T HolM W Draper
May 7, 1998·The International Journal of Biochemistry & Cell Biology·D S Latchman
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·V J HilserE Freire
Apr 14, 1999·Nature Structural Biology·W A EatonA Mozzarelli
Jul 20, 1999·Annual Review of Biophysics and Biomolecular Structure·U HauptsD Oesterhelt
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·T A Duke, D Bray
Nov 5, 1999·Journal of Molecular Biology·P E Wright, H J Dyson
Oct 18, 2000·Proceedings of the National Academy of Sciences of the United States of America·H PanV J Hilser
May 1, 2001·Journal of Molecular Biology·T A DukeD Bray
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·E W Yu, D E Koshland
Jan 26, 2002·Cell Motility and the Cytoskeleton·Matthew J Tyska, David M Warshaw
Feb 13, 2002·Current Opinion in Structural Biology·Wendell A Lim
May 4, 2002·Annual Review of Biophysics and Biomolecular Structure·Irene LuqueErnesto Freire
Jul 20, 2002·Biophysical Chemistry·Eric R HenryWilliam A Eaton
Nov 1, 2002·Cell·Ofer Yifrach, Roderick MacKinnon
Jan 1, 1961·Cold Spring Harbor Symposia on Quantitative Biology·J P CHANGEUX
May 1, 1965·Journal of Molecular Biology·J MONODJ P CHANGEUX
Jan 1, 1961·Cold Spring Harbor Symposia on Quantitative Biology·J MONOD, F JACOB
May 7, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Raj Kumar, E Brad Thompson
Jun 4, 2005·Science·Jean-Pierre Changeux, Stuart J Edelstein
Apr 1, 1935·Proceedings of the National Academy of Sciences of the United States of America·L Pauling
Feb 1, 1958·Proceedings of the National Academy of Sciences of the United States of America·D E Koshland
Jun 21, 2006·Biochemistry·Michael W ClarksonAndrew L Lee
Aug 15, 2006·Nature Structural & Molecular Biology·Nataliya PopovychCharalampos G Kalodimos
Oct 3, 2006·Journal of Molecular Biology·Ernesto J FuentesAndrew L Lee
Feb 14, 2007·Proteins·Michael D Daily, Jeffrey J Gray
Apr 20, 2007·Nature·Prasad PurohitAnthony Auerbach
May 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Vincent J Hilser, E Brad Thompson
Aug 19, 2007·IUBMB Life·William A EatonAndrea Mozzarelli
Jun 19, 2008·Protein Science : a Publication of the Protein Society·Qiang Cui, Martin Karplus
Feb 21, 2009·PLoS Computational Biology·Michael D Daily, Jeffrey J Gray
Mar 24, 2009·FEBS Letters·Roman A LaskowskiJanet M Thornton
Apr 10, 2009·Current Protein & Peptide Science·Matthew J Whitley, Andrew L Lee
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Travis P SchrankVincent J Hilser
Oct 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Chad M PetitAndrew L Lee
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sean E ReichheldAlan R Davidson
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Gustavo J RodriguezTheodore G Wensel

❮ Previous
Next ❯

Citations

Dec 18, 2013·PLoS Computational Biology·Ayse Ozlem AykutCanan Atilgan
Feb 12, 2014·PLoS Computational Biology·Chung-Jung Tsai, Ruth Nussinov
Jan 22, 2014·Nature Communications·Guifeng LiR Brian Dyer
Apr 25, 2014·Nature Communications·Moon-Hyeong SeoHak-Sung Kim
Aug 29, 2014·Journal of the Royal Society, Interface·Tobias Sikosek, Hue Sun Chan
Aug 21, 2014·Proceedings of the National Academy of Sciences of the United States of America·Cristiano ViappianiWilliam A Eaton
Aug 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Sarah L ShammasJane Clarke
Sep 15, 2014·Nature Chemical Biology·Lee FreiburgerAnthony Mittermaier
Mar 26, 2013·Nature Chemical Biology·Sathish SrinivasanKendall W Nettles
Feb 16, 2013·The Journal of Biological Chemistry·Rheanna SandWarren J Gallin
Jan 8, 2016·Chemical Reviews·Andre A S T Ribeiro, Vanessa Ortiz
Feb 20, 2016·Chemical Reviews·Nikolay V Dokholyan
Apr 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Lihong ChenJiandong Chen
Aug 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·A Carl WhittingtonBrian G Miller
Jan 29, 2013·Journal of Molecular Biology·Gregory C CampanelloDavid P Giedroc
Jan 12, 2016·Chemical Reviews·A Clay Clark
Jan 7, 2016·Chemical Reviews·George P Lisi, J Patrick Loria
Nov 13, 2015·Biochemistry·Wilfredo EvangelistaJohn C Lee
Oct 13, 2014·Trends in Genetics : TIG·Srivatsan RamanGeorge M Church
Mar 17, 2016·The Journal of Chemical Physics·Prithviraj Nandigrami, John J Portman
Jan 13, 2015·Methods : a Companion to Methods in Enzymology·Lee FreiburgerAnthony Mittermaier
Sep 5, 2013·Protein Science : a Publication of the Protein Society·Young-Joo YunJeong-Yong Suh
May 15, 2013·Biophysical Journal·Bob Eisenberg
Jul 28, 2015·Journal of Biomolecular Structure & Dynamics·Soumendra RanaBharat Kumar Majhi
Sep 20, 2012·Biochemical Society Transactions·Hesam N MotlaghVincent J Hilser
Jun 25, 2013·Biochimica Et Biophysica Acta·Christian Seifert, Frauke Gräter
Aug 21, 2013·Journal of Molecular Biology·Modupeola A SowoleLars Konermann
Mar 19, 2013·Journal of Molecular Biology·Sarah MarzenRob Phillips
Apr 16, 2013·Journal of Molecular Biology·Shibani BhattacharyaZimei Bu
Mar 22, 2015·Current Opinion in Structural Biology·Luisa Di Paola, Alessandro Giuliani
Apr 16, 2013·Cell·Ruth Nussinov, Chung-Jung Tsai
Mar 1, 2015·Annual Review of Condensed Matter Physics·Rob Phillips
May 23, 2015·Biophysics Reviews·Philip D TownsendMartin J Cann
Apr 23, 2015·Nature Communications·Jay H ChoiMarc Ostermeier
Mar 26, 2013·Biochimica Et Biophysica Acta·Luca RondaStefano Bettati
May 7, 2013·Biochimica Et Biophysica Acta·Takashi Yonetani, Kenji Kanaori
Jun 14, 2016·Cellular Logistics·Neeladri Sekhar RoyJames M Gruschus

❮ Previous
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