Structural and functional abnormality of the putamen in children with developmental dyslexia

Neuropsychologia
Zhao WangFan Cao

Abstract

There is currently debate with regards to the role of phonological deficit in Chinese reading difficulty, even though some researchers have suggested that the deficit of phonological processing is also a signature of developmental dyslexia in Chinese, as has been found in alphabetic languages. In this study, we examined the brain mechanisms of phonological deficit in Chinese children with developmental dyslexia (DD) during an auditory rhyming judgment task. First, we examined structural differences in Chinese dyslexia by comparing gray and white matter volume in Chinese children with DD, age-matched controls (AC), and reading-matched controls (RC). Next, we examined whether the regions with an abnormal volume in DD showed deficient functional connectivity with the rest of the brain during a phonological task (i.e. auditory rhyming judgment). We found that both AC and RC had greater gray matter volume (GMV) at the left putamen and right dorsal lateral frontal cortex than DD, suggesting possible neural signatures of developmental dyslexia. Functional connectivity analysis revealed that the left putamen was more connected with the right inferior occipital gyrus (IOG) in AC and RC than in DD, suggesting that automatic orthographic ...Continue Reading

Citations

Dec 15, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Virginia E SturmMaria Luisa Gorno-Tempini
Apr 8, 2021·Journal of the International Neuropsychological Society : JINS·Atheer Odah MassarweYafit Gabay
Jul 23, 2021·NeuroImage·Aleksi J SihvonenTeija Kujala
Sep 12, 2021·Neurobiology of Learning and Memory·Yafit Gabay
Apr 19, 2020·NeuroImage·Alexander EngeMichael A Skeide

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