Structural and functional analyses of the sixth site of neurexin alternative splicing

Doklady. Biochemistry and Biophysics
O V SerovaA G Petrenko

Abstract

In this study, we found the sixth site of alternative splicing (SS6) of neurexin 1a from the rat brain. This site is located between the fifth LNS and the third EGF-like domains. The insertion in the SS6 site corresponds to the 9-residue peptide VALMKADLQ, which is conserved among animals. We demonstrated that the SS6 insertion regulates tissue-specific expression of neurexin 1α.

References

Jan 1, 1992·Cold Spring Harbor Symposia on Quantitative Biology·M GeppertT C Südhof
Nov 5, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Akira SaitoHiroshi Kawachi
Feb 6, 2014·Journal of Molecular Neuroscience : MN·Yves Bourne, Pascale Marchot
Oct 30, 2014·The Journal of Biological Chemistry·Zhuoyang LuGabby Rudenko

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Citations

Sep 9, 2018·Journal of Molecular Biology·Jianfang LiuGabby Rudenko

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