PMID: 7522912Sep 1, 1993Paper

Structural and functional aspects of P-glycoproteins and related transport proteins

Current Opinion in Nephrology and Hypertension
P Lepage, P Gros

Abstract

The emergence of multidrug resistance in tumor cells is caused by the expression of P-glycoprotein. P-glycoprotein has a unique structure formed by two homologous halves, each encoding six putative transmembrane segments and one nucleotide binding fold. This structural arrangement has been conserved in a large number of eukaryotic and prokaryotic membrane transport systems, which together form the ATP binding cassette superfamily. These membrane transporters act on different groups of substrates in different cell types and organisms. The combined molecular analysis of these proteins has shed light on the mechanism by which P-glycoprotein acts on structurally unrelated groups of chemotherapeutic drugs and has allowed the identification of the protein domain responsible for the common mechanism of transport and recognition of substrate molecules. The function of P-glycoprotein in normal tissues remains intriguing and is discussed in this review.

Citations

Apr 11, 2012·International Journal of Molecular Sciences·Shuwen YuFengshan Wang
Dec 1, 2001·Expert Opinion on Biological Therapy·V AlakhovA Kabanov
Jul 5, 2005·Expert Opinion on Investigational Drugs·V Y Alakhov, A V Kabanov
Feb 6, 2007·Molecular Pharmaceutics·Robert F BattistiDuxin Sun

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