Structural and functional asymmetry of the language network emerge in early childhood

Developmental Cognitive Neuroscience
Jess E ReynoldsCatherine Lebel

Abstract

Structural and functional neuroimaging studies show language and reading processes are left-lateralized, and associated with a dispersed group of left brain regions. However, it is unclear when and how asymmetry of these regions emerges. We characterized the development of structural and functional asymmetry of the language network in 386 datasets from 117 healthy children (58 male) across early childhood (2-7.5 years). Structural asymmetry was investigated using diffusion tensor imaging (DTI) and manual delineation of the arcuate fasciculus. Functional connectivity asymmetry was calculated from seed regions in the inferior frontal gyrus (IFG) and middle temporal gyrus (MTG). We show that macrostructural asymmetry of the arcuate fasciculus is present by age 2 years, while leftward asymmetry of microstructure and functional connectivity with the IFG increases across the age range. This emerging microstructural and functional asymmetry likely underlie the development of language and reading skills during this time.

Citations

Feb 3, 2021·NPJ Science of Learning·Katarzyna ChylKatarzyna Jednoróg
Feb 20, 2020·Data in Brief·Jess E ReynoldsCatherine Lebel
Jun 14, 2021·Developmental Cognitive Neuroscience·Jennifer ZukNadine Gaab
Jul 20, 2021·Developmental Science·Curtis OstertagCatherine Lebel

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Methods Mentioned

BETA
sedation

Software Mentioned

BrainNet Viewer
3dClustSim
3dFWHMx
ExploreDTI
lmerTest
lme4
FSL
SPSS
AFNI

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