Structural and functional cardiac profile after prolonged duration of mechanical unloading: potential implications for myocardial recovery

American Journal of Physiology. Heart and Circulatory Physiology
Estibaliz CastilleroIsaac George

Abstract

Clinical and experimental studies have suggested that the duration of left ventricular assist device (LVAD) support may affect remodeling of the failing heart. We aimed to 1) characterize the changes in Ca2+/calmodulin-dependent protein kinase type-IIδ (CaMKIIδ), growth signaling, structural proteins, fibrosis, apoptosis, and gene expression before and after LVAD support and 2) assess whether the duration of support correlated with improvement or worsening of reverse remodeling. Left ventricular apex tissue and serum pairs were collected in patients with dilated cardiomyopathy ( n = 25, 23 men and 2 women) at LVAD implantation and after LVAD support at cardiac transplantation/LVAD explantation. Normal cardiac tissue was obtained from healthy hearts ( n = 4) and normal serum from age-matched control hearts ( n = 4). The duration of LVAD support ranged from 48 to 1,170 days (median duration: 270 days). LVAD support was associated with CaMKIIδ activation, increased nuclear myocyte enhancer factor 2, sustained histone deacetylase-4 phosphorylation, increased circulating and cardiac myostatin (MSTN) and MSTN signaling mediated by SMAD2, ongoing structural protein dysregulation and sustained fibrosis and apoptosis (all P < 0.05). Inc...Continue Reading

References

Apr 28, 2001·The Journal of Thoracic and Cardiovascular Surgery·J D MadiganD Burkhoff
Apr 3, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Simon MaybaumDonna Mancini
Jan 22, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Brian A BrucknerKeith Youker
Sep 27, 2006·European Heart Journal·Stephane LaurentUNKNOWN European Network for Non-invasive Investigation of Large Arteries
Nov 3, 2006·The New England Journal of Medicine·Emma J BirksMagdi H Yacoub
Jan 20, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Wunimenghe OriyanhanMasashi Komeda
Apr 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Tsung-Ming LeeNen-Chung Chang
May 16, 2008·The New England Journal of Medicine·Eugene Braunwald
Oct 14, 2008·Journal of Molecular and Cellular Cardiology·Alexander P SchwoererAli El-Armouche
Dec 2, 2009·Autophagy·Kari Wellnitz, Heinrich Taegtmeyer
Jan 2, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Monique L OgletreeChristine S Moravec
Feb 1, 2011·Journal of Molecular and Cellular Cardiology·Mark E AndersonDonald M Bers
May 5, 2012·Journal of Cardiac Failure·Daniel J GoldsteinUNKNOWN HeartMate II Clinical Investigators
Aug 28, 2012·Stroke; a Journal of Cerebral Circulation·Alastair J S WebbPeter M Rothwell
Oct 30, 2012·Bioinformatics·Alexander DobinThomas R Gingeras
Dec 18, 2012·Cellular and Molecular Bioengineering·Danika M HaymanHai-Chao Han
Jul 13, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Stefanie WaltherJens Kockskämper
Jun 10, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Estibaliz CastilleroIsaac George
Nov 4, 2016·Expert Review of Medical Devices·Van-Khue TonVeli K Topkara
Apr 22, 2017·Naunyn-Schmiedeberg's Archives of Pharmacology·Andrzej WróbelJarosław Dudka
May 5, 2017·JCI Insight·Ruiping JiP Christian Schulze
May 28, 2017·The Journal of Experimental Medicine·Takuma TsudaToyoaki Murohara
Oct 19, 2017·Current Hypertension Reports·Francesco CastagnaBarry J McDonnell
Mar 13, 2018·The New England Journal of Medicine·Mandeep R MehraUNKNOWN MOMENTUM 3 Investigators

❮ Previous
Next ❯

Citations

Sep 8, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Hai-Chao Han
Aug 2, 2019·The Journal of General Physiology·Vani S RavichandranMargaret V Westfall
Dec 31, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Estibaliz CastilleroIsaac George
May 14, 2021·Circulation Research·Daniel BurkhoffNir Uriel

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

Rsubread
R
DESeq2
STAR

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Artificial Heart & Ventricular Assist Devices

Total artificial hearts (TAH) and ventricular assist devices (VADs) provide cardiac support for patients with end-stage heart disease and have significantly improved the survival of these patients. Discover the latest research on Artificial Heart and Ventricular Assist Devices here.

Related Papers

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Shunsuke SaitoYoshiki Sawa
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Bhagyalaxmi MohapatraMatteo Vatta
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Leanne E FelkinPaul J R Barton
© 2022 Meta ULC. All rights reserved