Structural and functional changes in diabetic glomerulopathy

Kidney & Blood Pressure Research
E SchleicherA Nerlich

Abstract

Diabetic nephropathy is characterized by glomerular basement membrane thickening and mesangial expansion. Immunohistochemical studies of diabetic kidneys showed an increased collagen type IV synthesis and deposition in the mesangial matrix, while the glomerular heparan sulfate proteoglycan content was decreased. In nodular glomerulosclerosis massive deposition of collagens III and VI appears, possibly indicating irreversibility of the pathological process. These structural changes seem to be the underlying cause for the alterations of renal functions like persistent albuminuria and proteinura. In a recent study significant glomerular infiltration by macrophages at all stages of glomerulosclerosis was observed. The pathogenesis of the multitude of cellular, structural, and functional abnormalities in diabetic nephropathy is likely to be multifactorial, involving chronic hyperglycemia as well as genetic determinants. In vitro studies with cultured glomerular cells have indicated that hyperglycemia induces transforming growth factor beta, a matrix-producing cytokine. The hyperglycemia-induced cytokine production may involve protein kinase C activation and/or the formation of advanced glucosylation end products. The elucidation of ...Continue Reading

Citations

May 12, 2007·The Review of Diabetic Studies : RDS·Visith ThongboonkerdJon B Klein
Dec 1, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S YoonM Bendayan
Oct 7, 2015·Clinical and Experimental Nephrology·Yuki MatsuiHitoshi Yokoyama
Jun 20, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·K WeltG Fitzl
Jan 8, 2005·Nephron. Physiology·Claudio M Joo TuroniMaría Peral de Bruno
Apr 14, 2018·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·S O Akarca-DizakarA Uysal
Jul 30, 1999·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·M Regoli, M Bendayan
May 1, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P MenèG Gambaro
Feb 1, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Heiko MetheElazer R Edelman
Jan 1, 2014·Journal of Diabetes and Metabolic Disorders·Gurusiddaiah Suresh Kumar, Paramahans Veerayya Salimath
Oct 21, 2010·American Journal of Physiology. Endocrinology and Metabolism·Dongjuan ZhangYoufei Guan

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