Structural and functional changes in retinal vasculature induced by retinal ischemia-reperfusion in rats

Experimental Eye Research
Tsutomu NakaharaKunio Ishii

Abstract

Recent studies have shown retinal blood vessel damage in experimental models of retinal degeneration. The present study aimed to provide a detailed description of the structural and functional changes in retinal vasculature induced by retinal ischemia-reperfusion (I/R) in rats. Retinal ischemia was induced for 60 min by raising the intraocular pressure to 130 mmHg. Morphological changes in vascular components (endothelial cells, pericytes, and basement membranes), the patency and perfusion of blood vessels, and expression of vascular endothelial growth factor (VEGF) were assessed in the retinas at 2, 7, and 14 days after I/R. Significant reductions in vascular densities were observed at 7 and 14 days after I/R. Pericyte loss occurred after the appearance of endothelial cell degeneration, whereas the vascular basement membranes remained unchanged. Some vessels showed no perfusion in damaged retina. A decrease in the immunoreactivity of VEGF in the region extending from the ganglion cell layer to the outer plexiform layer was evident 2 days after I/R. In retinal I/R model, retinal ganglion cells are rapidly (<2 day) damaged following reperfusion, therefore, the current results suggest that neuronal cell damage precedes capillary ...Continue Reading

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Citations

May 20, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Biji MathewSteven Roth
Sep 30, 2018·Investigative Ophthalmology & Visual Science·Anri NishinakaHideaki Hara
Jun 9, 2020·Journal of Current Ophthalmology·Emine ÇiloğluNese Cetin Dogan
Sep 11, 2020·Journal of Clinical Medicine·Klaudia RakusiewiczLidia Ziółkowska
Sep 12, 2019·Current Diabetes Reports·Avinash HonasogeRithwick Rajagopal
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Jul 19, 2019·Eye·Emine CilogluNeşe Çetin Dogan
Sep 3, 2019·Experimental Eye Research·Qingchen LiChunhui Jiang
Feb 12, 2021·European Journal of Ophthalmology·Safaa Awad-Allah AboudSamar Said Ahmed
Oct 13, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mojtaba AbrishamiMajid Abrishami
Apr 30, 2021·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Juan San Cristóbal EpalzaBorja Herrero de la Parte

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