Structural and functional changes of the human macula during acute exposure to high altitude.

PloS One
M Dominik FischerFlorian Gekeler

Abstract

This study aimed to quantify structural and functional changes at the macula during acute exposure to high altitude and to assess their structure/function relationship. This work is related to the Tuebingen High Altitude Ophthalmology (THAO) study. Spectral domain optical coherence tomography and microperimetry were used to quantify changes of central retinal structure and function in 14 healthy subjects during acute exposure to high altitude (4559 m). High-resolution volume scans and fundus-controlled microperimetry of the posterior pole were performed in addition to best-corrected visual acuity (BCVA) measurements and assessment of acute mountain sickness. Analysis of measurements at altitude vs. baseline revealed increased total retinal thickness (TRT) in all four outer ETDRS grid subfields during acute altitude exposure (TRT(outer) = 2.80 ± 1.00 μm; mean change ± 95%CI). This change was inverted towards the inner four subfields (TRT(inner) = -1.89 ± 0.97 μm) with significant reduction of TRT in the fovea (TRT(foveal) = -6.62 ± 0.90 μm) at altitude. BCVA revealed no significant difference compared to baseline (0.06 ± 0.08 logMAR). Microperimetry showed stable mean sensitivity in all but the foveal subfield (MS(foveal) = -1.1...Continue Reading

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Citations

Sep 10, 2014·Journal français d'ophtalmologie·A RussoC Dot
Sep 22, 2012·High Altitude Medicine & Biology·Christian Grimm, Gabriel Willmann
Jul 21, 2012·Journal of Cataract and Refractive Surgery·Thomas Kohnen
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Jun 28, 2014·High Altitude Medicine & Biology·Gabriel WillmannPeter Bärtsch
Jun 28, 2014·High Altitude Medicine & Biology·Gabriel WillmannKatrin Gekeler
Nov 21, 2019·High Altitude Medicine & Biology·Till KruschePetra Platen
Mar 7, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Immanuel P SeitzM Dominik Fischer
Jun 1, 2013·Journal of Applied Physiology·Andreas SchatzFlorian Gekeler

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Methods Mentioned

BETA
IEC

Software Mentioned

Eye Explorer
Spectralis Viewing Module
MultiModalMapper
JMP®
NAVIS

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