Structural and functional changes of the visual cortex in early Huntington's disease

Human Brain Mapping
Emma M CoppenRaymund A C Roos

Abstract

Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disorder characterized by motor disturbances, psychiatric disturbances, and cognitive impairment. Visual cognitive deficits and atrophy of the posterior cerebral cortex are additionally present in early disease stages. This study aimed to assess the extent of structural and functional brain alterations of the visual cortex in HD gene carriers using different neuroimaging modalities. Structural and functional magnetic resonance imaging data were acquired from 18 healthy controls, 21 premanifest, and 20 manifest HD gene carriers. Voxel-based morphometry (VBM) analysis and cortical thickness measurements were performed to assess structural changes in the visual cortex. Brain function was measured by assessing neuronal connectivity changes in response to visual stimulation and at rest in visual resting-state networks. Multiple linear regression analyses were performed to examine the relationship between visual cognitive function and structural imaging measures. Compared to controls, pronounced atrophy and decreased neuronal function at rest were present in associative visual cortices in manifest HD. The primary visual cortex did not show group difference...Continue Reading

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Citations

Jan 11, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Frederic SampedroJaime Kulisevsky
Feb 8, 2020·Journal of Neurology·Saul Martinez-HortaUNKNOWN Cognitive Phenotype Working Group of the European Huntington’s Disease Network
Nov 10, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Ignacio Aracil-BolañosJaime Kulisevsky

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Software Mentioned

Statistical Package for Social Sciences ( SPSS
FreeSurfer
TFCE
UniQure
R
SPSS
FMRIB Software Library ( FSL
FSL
FEAT

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