Structural and functional characterization of a second subfamily member of the calcium-modulated bovine rod outer segment membrane guanylate cyclase, ROS-GC2

Biochemical and Biophysical Research Communications
R GoraczniakR K Sharma

Abstract

A native bovine calcium-modulated rod outer segment membrane guanylate cyclase (ROS-GC) has been cloned and reconstituted to show its linkage consistent to the process of phototransduction. In the present study, a second form of the membrane guanylate cyclase has been cloned from the bovine retina. This cyclase shares a high sequence identity with ROS-GC, is specifically expressed in the bovine retina, and, like ROS-GC, is modulated in low Ca2+ by a calmodulin-like Ca2+-binding protein, termed GCAP2. For this reason, this cyclase has now been named ROS-GC2 and the previously described ROS-GC as ROS-GC1. The tail end of ROS-GC2 contains a stretch of five amino acids, a structural feature unique to itself. These findings support the existence of a calcium-modulated subfamily of ROS-GC and indicate that ROS-GC2 embodies a five amino acid signature element at its tail end.

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Citations

May 27, 2008·Biochemistry·Venkateswar VenkataramanRameshwar K Sharma
Feb 6, 2007·Molecular and Cellular Biochemistry·Beata BurczynskaRameshwar K Sharma
Jun 9, 2000·Annual Review of Neuroscience·A D Gibson, D L Garbers
Sep 18, 2007·Journal of Neurochemistry·Andreas HeltenKarl-Wilhelm Koch
May 27, 2014·Frontiers in Molecular Neuroscience·Shannon E Boye
Apr 12, 2014·Frontiers in Molecular Neuroscience·Rameshwar K SharmaTeresa Duda
Oct 4, 2016·Frontiers in Molecular Neuroscience·Rameshwar K SharmaClint L Makino
Feb 11, 2018·Molecular and Cellular Biochemistry·Teresa DudaRameshwar K Sharma
May 21, 1999·The Journal of Biological Chemistry·H YuA Yamazaki
Jun 12, 2003·The Journal of Biological Chemistry·Akio YamazakiRussell K Yamazaki
Dec 4, 2009·Molecular and Cellular Biochemistry·Rameshwar K Sharma
Nov 27, 2009·Molecular and Cellular Biochemistry·David M HuntMichel Michaelides
Aug 22, 2020·Translational Vision Science & Technology·Xiao LiuUNKNOWN Japan Eye Genetics Consortium
May 8, 1998·Biochemical and Biophysical Research Communications·R M GoraczniakR K Sharma
Dec 3, 1999·Methods : a Companion to Methods in Enzymology·A M Dizhoor, J B Hurley

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