PMID: 8938711Jan 1, 1996Paper

Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B)

Neuropharmacology
T LeicherOlaf Pongs

Abstract

Voltage-activated Shaker-related potassium channels (kv1) consist of alpha and beta subunits. We have analysed the structure of the human KCNA1B (hKv beta 1) gene. KCNA1B is > 250 kb in size and encodes at least three Kv beta 1 splice variants. The Kv beta 1 open reading frame is divided into 14 exons. In contrast, genes coding for family members of KCNA (Kv 1 alpha) subunits are markedly smaller and have intronless open reading frames. The expression of Kv 1 alpha and Kv beta mRNA was compared in Northern blots of poly(A+) RNA isolated from various human brain tissues. The results suggest an intricate and cell-specific regulation of Kv 1 alpha and Kv beta mRNA synthesis such that distinct combinations of alpha and beta subunits would occur in different nuclei of the brain. The splice variants hKv beta 1.1 and hKv beta 1.2 were functionally characterized in coexpression studies with hKv 1.5 alpha subunits in 293 cells. It is shown that the confer rapid inactivation on hKv 1.5 channels with different potencies. This may be due to differences in their amino terminal sequences and/or inactivating domains. It is also shown that the amino terminal Kv beta 1.1 and Kv 1.4 alpha inactivating domains compete with each other, probably fo...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
May 1, 1992·Trends in Neurosciences·L SalkoffA Wei
Jan 1, 1992·Annual Review of Physiology·L Y Jan, Y N Jan
Aug 22, 1991·Proceedings. Biological Sciences·M StockerJ P Ruppersberg
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H Rehm, M Lazdunski
Jun 1, 1988·Neuroscience·B Rudy
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Dec 1, 1995·The Journal of Biological Chemistry·S K EnglandM M Tamkun
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·S W ChouinardB Ganetzky
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·S K EnglandM M Tamkun
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·V E ScottJ O Dolly
Jun 15, 1996·The Journal of Physiology·S H HeinemannO Pongs

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Citations

Feb 22, 2005·Genes, Brain, and Behavior·J X ConnorA Messing
Jul 22, 1999·Annals of the New York Academy of Sciences·O PongsJ F Storm
Feb 24, 2004·Annual Review of Physiology·James S Trimmer, Kenneth J Rhodes
Oct 17, 2008·Physiological Reviews·Helene VacherJames S Trimmer
Jan 11, 2005·Journal of Neuroscience Research·Bernd SokolowskiDmytro Duzhyy
Dec 19, 2009·American Journal of Physiology. Cell Physiology·Elyssa D BurgJason X-J Yuan
Apr 16, 2010·Physiological Reviews·Olaf Pongs, Jürgen R Schwarz
Dec 18, 1998·The Journal of Biological Chemistry·T LeicherO Pongs

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