Structural and functional connectivity in traumatic brain injury

Neural Regeneration Research
Hui XiaoZi-Qian Chen

Abstract

Traumatic brain injury survivors often experience cognitive deficits and neuropsychiatric symptoms. However, the neurobiological mechanisms underlying specific impairments are not fully understood. Advances in neuroimaging techniques (such as diffusion tensor imaging and functional MRI) have given us new insights on structural and functional connectivity patterns of the human brain in both health and disease. The connectome derived from connectivity maps reflects the entire constellation of distributed brain networks. Using these powerful neuroimaging approaches, changes at the microstructural level can be detected through regional and global properties of neuronal networks. Here we will review recent developments in the study of brain network abnormalities in traumatic brain injury, mainly focusing on structural and functional connectivity. Some connectomic studies have provided interesting insights into the neurological dysfunction that occurs following traumatic brain injury. These techniques could eventually be helpful in developing imaging biomarkers of cognitive and neurobehavioral sequelae, as well as predicting outcome and prognosis.

Citations

Jun 1, 2016·Frontiers in Systems Neuroscience·John A Wolf, Paul F Koch
Nov 25, 2017·Neural Regeneration Research·Hui XiaoZi-Qian Chen
Jan 13, 2018·Molecular Neurobiology·Farzad SalehpourMichael R Hamblin
Oct 9, 2019·Epilepsia·Rachael GarnerDominique Duncan
Mar 19, 2020·Brain Connectivity·Pedro Henrique Rodrigues da SilvaRenata Ferranti Leoni
Nov 26, 2016·Experimental Brain Research·Elena ShumskayaRoy P C Kessels
Nov 22, 2016·Medical Gas Research·Qin HuJohn H Zhang
Nov 7, 2018·Nature Reviews. Neurology·Tatyana MollayevaAngela Colantonio
Oct 16, 2020·The International Journal of Neuroscience·Rutvi Prajapati, Isaac Arnold Emerson
Aug 28, 2020·Behavioural Brain Research·Chandni ShethDeborah Yurgelun-Todd

❮ Previous
Next ❯

Software Mentioned

RS
fMRI

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.