Structural and functional consequences of trolox C treatment in the rat model of postnatal hyperoxia

Investigative Ophthalmology & Visual Science
Allison Lindsay DorfmanPierre Lachapelle

Abstract

Previous studies have shown that newborn rats exposed to hyperoxia within the first 2 weeks of life develop vasculopathy in addition to permanent changes in retinal structure and function. It has also been suggested that free radicals may be the source of these pathologic effects. Trolox C, a water-soluble analogue of vitamin E, was previously shown to limit the vascular consequences of exposure to postnatal hyperoxia. The aim of this study was to investigate whether trolox C could also help prevent the functional (electroretinography) and structural (retinal histology) consequences associated with oxygen-induced retinopathy (OIR). Newborn albino Sprague-Dawley rats exposed or not exposed to hyperoxia received daily injections of trolox C in doses of 300, 600, and 900 microg/kg (total volume, 50 microL). The effect of treatment was evaluated through electroretinography and retinal histology. Although trolox C tended to have a retinoactive effect on the normal retina, normalization of the hyperoxia-treated group to hyperoxic control and of the normoxia-treated group to normoxic control revealed that the a-wave remained relatively unaffected by hyperoxia exposure and by treatment with trolox C, the efficacy of trolox C at doses o...Continue Reading

Citations

Feb 9, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Massimo Dal MontePaola Bagnoli
May 17, 2008·Documenta Ophthalmologica. Advances in Ophthalmology·A L DorfmanP Lachapelle
Dec 17, 2009·Documenta Ophthalmologica. Advances in Ophthalmology·A L DorfmanP Lachapelle
Nov 6, 2012·Oxidative Medicine and Cellular Longevity·Suk-Yee LiAmy C Y Lo
Jul 1, 2009·Progress in Retinal and Eye Research·Anne B FultonJames D Akula

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