Structural and functional dysconnectivity of the fronto-thalamic system in schizophrenia: a DCM-DTI study

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Gerd WagnerKathrin Koch

Abstract

Evidence suggests that cognitive deficits are a core feature of schizophrenia. The concept of "cognitive dysmetria" has been introduced to characterize disintegration of fronto-thalamic-cerebellar circuitry which constitutes a key network for a variety of neuropsychological symptoms in schizophrenia. The present multimodal study aimed at investigating effective and structural connectivity of the fronto-thalamic circuitry in schizophrenia. fMRI effective connectivity analysis using dynamic causal modeling (DCM) and diffusion tensor imaging (DTI) were combined to examine cognitive control processes in 38 patients with schizophrenia and 40 matched healthy controls. Significantly lower fractional anisotropy (FA) was detected in patients in the right anterior limb of the internal capsule (ALIC), the right thalamus and the right corpus callosum. During Stroop task performance patients demonstrated significantly lower activation relative to healthy controls in a predominantly right lateralized fronto-thalamo-cerebellar network. An abnormal effective connectivity was observed in the right connections between thalamus, anterior cingulate and dorsolateral prefrontal cortex. FA in the ALIC was significantly correlated with the thalamic BO...Continue Reading

References

Sep 1, 1975·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·G G Briggs, R D Nebes
Mar 11, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S Murray Sherman, R W Guillery
Oct 31, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T E J BehrensS M Smith
May 4, 2004·Trends in Cognitive Sciences·Stewart Shipp
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Jul 19, 2005·Journal of Psychiatric Research·Marek KubickiMartha E Shenton
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Jan 15, 2008·Cognitive, Affective & Behavioral Neuroscience·Cameron S Carter, Vincent van Veen
Jan 23, 2008·Nature Reviews. Neuroscience·Luiz Pessoa
Apr 11, 2008·Biological Psychiatry·Deanna M Barch, Ed Smith
Jun 6, 2008·European Psychiatry : the Journal of the Association of European Psychiatrists·Marinos KyriakopoulosSophia Frangou
Oct 28, 2008·Brain Research Bulletin·Suzanne N Haber, Roberta Calzavara
Aug 5, 2009·Archives of General Psychiatry·Michael J MinzenbergDavid C Glahn
Mar 20, 2010·PLoS Computational Biology·Will D PennyAlex P Leff
Jul 14, 2010·Psychiatry Research·Daniel MamahJohn G Csernansky
Nov 9, 2010·Psychiatry Research·James J LevittMartha E Shenton
Dec 15, 2010·Frontiers in Systems Neuroscience·Kevin N O'ConnorMitchell L Sutter
May 25, 2011·Neuroscience and Biobehavioral Reviews·Yumiko Watanabe, Shintaro Funahashi
Jul 28, 2011·Neuron·Yuri B Saalmann, Sabine Kastner
Jan 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christian K TamnesKristine B Walhovd
Sep 21, 2012·Nature Reviews. Neuroscience·Charan Ranganath, Maureen Ritchey
Oct 4, 2012·The American Journal of Psychiatry·Neil D WoodwardStephan Heckers
Jun 4, 2013·Schizophrenia Research·François OrliacPascal Delamillieure

❮ Previous
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Citations

Mar 27, 2016·Human Brain Mapping·Stéphanie LefebvreRenaud Jardri
May 22, 2016·Brain Stimulation·Louis-Philippe LafleurJean-Francois Lepage
Aug 2, 2016·The Journal of Nervous and Mental Disease·Guusje Collin, René S Kahn
Apr 14, 2016·The Australian and New Zealand Journal of Psychiatry·Jerome J MallerPaul B Fitzgerald
Feb 24, 2017·Nature Neuroscience·Michael Breakspear
Sep 2, 2017·Journal of Neurosurgery·Joshua D BurksMichael E Sughrue
Jul 19, 2018·Brain : a Journal of Neurology·Tineke Grent-'t-JongPeter J Uhlhaas
Feb 23, 2019·The British Journal of Psychiatry : the Journal of Mental Science·Jinnan GongDezhong Yao
Jun 15, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mihai AvramChristian Sorg
Apr 18, 2017·Nordic Journal of Psychiatry·Mitsuo OkitaShu-Ichi Ueno
Jul 16, 2017·The Cerebellum·Maximilian CierpkaRobert Christian Wolf
Jun 8, 2018·Frontiers in Computational Neuroscience·Fali LiPeng Xu
Nov 6, 2018·Frontiers in Neuroscience·Andy SchumannKarl-Jürgen Bär
Apr 7, 2019·European Archives of Psychiatry and Clinical Neuroscience·Mu-Hong ChenJu-Wei Hsu
Oct 21, 2017·Brain : a Journal of Neurology·Natasza D OrlovSukhi S Shergill
Mar 24, 2018·AJNR. American Journal of Neuroradiology·K PietermanJ Dudink
Jan 30, 2020·Cerebellum & Ataxias·Joshua KrämerRobert Christian Wolf
Jan 26, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Flavien ThuaireMarie Izaute

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