Structural and functional evolution of the P2Y(12)-like receptor group.

Purinergic Signalling
Torsten SchönebergAngela Schulz

Abstract

Metabotropic pyrimidine and purine nucleotide receptors (P2Y receptors) belong to the superfamily of G protein-coupled receptors (GPCR). They are distinguishable from adenosine receptors (P1) as they bind adenine and/or uracil nucleotide triphosphates or diphosphates depending on the subtype. Over the past decade, P2Y receptors have been cloned from a variety of tissues and species, and as many as eight functional subtypes have been characterized. Most recently, several members of the P2Y(12)-like receptor group, which includes the clopidogrel-sensitive ADP receptor P2Y(12), have been deorphanized. The P2Y(12)-like receptor group comprises several structurally related GPCR which, however, display heterogeneous agonist specificity including nucleotides, their derivatives, and lipids. Besides the established function of P2Y(12) in platelet activation, expression in macrophages, neuronal and glial cells as well as recent results from functional studies implicate that several members of this group may have specific functions in neurotransmission, inflammation, chemotaxis, and response to tissue injury. This review focuses specifically on the structure-function relation and shortly summarizes some aspects of the physiological releva...Continue Reading

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Citations

May 15, 2009·PloS One·Iris BöseltTorsten Schöneberg
Dec 15, 2010·Journal of Receptor and Signal Transduction Research·Sonika BhatnagarRavi Pathak
Dec 17, 2015·Annual Review of Physiology·János Peti-PeterdiJennifer L Pluznick
Feb 22, 2012·The Biochemical Journal·Lars RitscherTorsten Schöneberg
Aug 22, 2014·Glia·Julia PreisslerAngela Schulz
Aug 1, 2019·Annals of the New York Academy of Sciences·Nicole ScholzTorsten Schöneberg
Aug 23, 2019·Physiological Reviews·Volker VallonBellamkonda K Kishore
May 23, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maxi CösterTorsten Schöneberg
Feb 11, 2020·British Journal of Pharmacology·Kenneth A JacobsonChrista E Müller
Jul 6, 2014·The Journal of Biological Chemistry·Jaroslawna MeisterAngela Schulz
May 26, 2017·Scientific Reports·Antje BrüserTorsten Schöneberg
Nov 26, 2010·The Journal of Biological Chemistry·Ines LiebscherAngela Schulz
Jun 23, 2021·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Duck-Hyun KimJae-Seong Lee

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