Structural and functional evolution of the translocator protein (18 kDa)

Current Molecular Medicine
Jinjiang FanV Papadopoulos

Abstract

Translocator proteins (TSPO) are the products of a family of genes that is evolutionarily conserved from bacteria to humans and expressed in most mammalian tissues and cells. Human TSPO (18 kDa) is expressed at high levels in steroid synthesizing endocrine tissues where it localizes to mitochondria and functions in the first step of steroid formation, the transport of cholesterol into the mitochondria. TSPO expression is elevated in cancerous tissues and during tissue injury, which has lead to the hypothesis that TSPO has roles in apoptosis and the maintenance of mitochondrial integrity. We recently identified a new paralog of Tspo in both the human and mouse. This paralog arose from an ancient gene duplication event before the divergence of the classes aves and mammals, and appears to have specialized tissue-, cell-, and organelle-specific functions. Evidence from the study of TSPO homologs in mammals, bacteria, and plants supports the conclusion that the TSPO family of proteins regulates specialized functions related to oxygen-mediated metabolism. In this review, we provide a comprehensive overview of the divergent function and evolutionary origin of Tspo genes in Bacteria, Archaea, and Eukarya domains.

Citations

Oct 20, 2012·Archives of Dermatological Research·Tatiana RukshaVassilios Papadopoulos
Dec 20, 2012·Oxidative Medicine and Cellular Longevity·Xiaolong QiJunjie Xiao
Jun 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jinjiang FanVassilios Papadopoulos
Jul 16, 2015·Journal of Medicinal Chemistry·Elisabetta BarresiClaudia Martini
Jun 9, 2016·International Journal of Molecular Sciences·Leo VeenmanMoshe Gavish
Sep 9, 2016·International Journal of Molecular Sciences·Gurpreet Manku, Martine Culty
Jun 8, 2018·International Journal of Molecular Sciences·Frederick Bonsack, Sangeetha Sukumari-Ramesh
May 13, 2014·Protein Science : a Publication of the Protein Society·Lukasz JaremkoMarkus Zweckstetter
Jul 17, 2016·The Journal of Endocrinology·Vimal Selvaraj, Lan N Tu
Feb 27, 2020·Journal of the Endocrine Society·Jinjiang FanVassilios Papadopoulos
Nov 28, 2015·Hormone Molecular Biology and Clinical Investigation·Sylvie Hauguel-de Mouzon, Luciana Lassance
Oct 28, 2014·Brain Pathology·Guo-Jun LiuRichard B Banati
Jan 13, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Erik NutmaBenjamin B Tournier
Oct 30, 2020·International Journal of Molecular Sciences·Giada CipollinaMarco Peviani
Jul 1, 2021·Journal of Bioenergetics and Biomembranes·Carrie HiserShelagh Ferguson-Miller

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