PMID: 11345195May 10, 2001Paper

Structural and functional hot spots in cytokine receptors

International Journal of Hematology
C J BagleyA F Lopez

Abstract

The activation of cytokine receptors is a stepwise process that depends on their specific interaction with cognate cytokines, the formation of oligomeric receptor complexes, and the initiation of cytoplasmic phosphorylation events. The recent determination of the structure of extracellular domains of several cytokine receptors allows comparison of their cytokine-binding surfaces. This comparison reveals a common structural framework that supports considerable diversity and adaptability of the binding surfaces that determine both the specificity and the orientation of subunits in the active receptor complex. These regions of the cytokine receptors have been targeted for the development of specific agonists and antagonists. The physical coupling of signaling intermediates to the intracellular domains of their receptors plays a major role in determining biological responses to cytokines. In this review, we focus principally on the receptors for cytokines of the granulocyte-macrophage colony-stimulating factor (GM-CSF) family and, where appropriate, compare them with related cytokine receptors. Several paradigms are beginning to emerge that focus on the ability of the extracellular portion of the cytokine receptor to recognize the ...Continue Reading

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Citations

Dec 7, 2006·Archives of Pharmacal Research·Hyun-Mo YangSang-Hun Jung
Oct 18, 2003·The Journal of Allergy and Clinical Immunology·Margarita Martinez-Moczygemba, David P Huston
Oct 5, 2007·Journal of Abnormal Child Psychology·Steve S LeeStephen P Hinshaw
Aug 30, 2007·The Journal of Pharmacy and Pharmacology·Terry B ErnestJames L Ford

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