Structural and Functional MRI Evidence for Distinct Medial Temporal and Prefrontal Roles in Context-dependent Relational Memory

Journal of Cognitive Neuroscience
Hillary SchwarbNeal J Cohen

Abstract

Declarative memory is supported by distributed brain networks in which the medial-temporal lobes (MTLs) and pFC serve as important hubs. Identifying the unique and shared contributions of these regions to successful memory performance is an active area of research, and a growing literature suggests that these structures often work together to support declarative memory. Here, we present data from a context-dependent relational memory task in which participants learned that individuals belonged in a single room in each of two buildings. Room assignment was consistent with an underlying contextual rule structure in which male and female participants were assigned to opposite sides of a building and the side assignment switched between buildings. In two experiments, neural correlates of performance on this task were evaluated using multiple neuroimaging tools: diffusion tensor imaging (Experiment 1), magnetic resonance elastography (Experiment 1), and functional MRI (Experiment 2). Structural and functional data from each individual modality provided complementary and consistent evidence that the hippocampus and the adjacent white matter tract (i.e., fornix) supported relational memory, whereas the ventromedial pFC/OFC (vmPFC/OFC)...Continue Reading

References

Nov 1, 1991·The Quarterly Journal of Experimental Psychology. A, Human Experimental Psychology·J Miller
Sep 1, 1993·Journal of Clinical and Experimental Neuropsychology·G A BakerP Slade
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·J A Dusek, H Eichenbaum
Sep 1, 1995·NeuroImage·K J Worsley, K J Friston
Aug 10, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G H Glover
Oct 8, 1999·Behavioural Brain Research·H Eichenbaum
Oct 28, 1999·Nature·E K Miller
Feb 24, 2001·Psychological Science·J D RyanN J Cohen
Apr 3, 2001·Annual Review of Neuroscience·E K Miller, J D Cohen
Oct 9, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K P PruessmannP Boesiger
Nov 1, 2001·Nature Neuroscience·H Eichenbaum
Nov 24, 2001·Behavioural Brain Research·H Eichenbaum
Dec 18, 2001·Neurocase·H J SpiersN Burgess
Sep 10, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Earl K MillerJonathan D Wallis
May 24, 2003·Brain Research. Cognitive Brain Research·Scott D SlotnickJohn Hart
Aug 2, 2003·Nature Reviews. Neuroscience·Jon S Simons, Hugo J Spiers
Oct 31, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T E J BehrensS M Smith
Apr 22, 2004·Hippocampus·Stephan HeckersDebra Titone
Nov 5, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cindy A BuckmasterPeter R Rapp
Aug 2, 2005·Trends in Cognitive Sciences·Anthony D WagnerRandy L Buckner
Nov 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christine Smith, Larry R Squire
Nov 11, 2005·Hippocampus·Charan RanganathJesse Rissman
Dec 24, 2005·Cerebral Cortex·Carol A Seger, Corinna M Cincotta
Jan 13, 2006·Biological Psychiatry·Noriomi KurokiMartha E Shenton
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Sep 15, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Raffael KalischRaymond J Dolan
Apr 10, 2007·Annual Review of Neuroscience·H EichenbaumC Ranganath
May 18, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Elke HattingenStefan Weidauer
Jan 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Deborah E Hannula, Charan Ranganath
Jun 4, 2008·Medical & Biological Engineering & Computing·Matthew D J McGarry, Elijah E W Van Houten
Jun 17, 2008·Nature Neuroscience·Dimitris TsivilisJohn P Aggleton

❮ Previous
Next ❯

Software Mentioned

- Based Spatial Statistics
Windows
FLIRT
FreeSurfer
FSL
Tract
FMRIB Diffusion Toolbox
FNIRT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.