Structural and functional organization of the ESCRT-I trafficking complex.

Cell
Michael S KostelanskyJames H Hurley

Abstract

The endosomal sorting complex required for transport (ESCRT) complexes are central to receptor downregulation, lysosome biogenesis, and budding of HIV. The yeast ESCRT-I complex contains the Vps23, Vps28, and Vps37 proteins, and its assembly is directed by the C-terminal steadiness box of Vps23, the N-terminal half of Vps28, and the C-terminal half of Vps37. The crystal structures of a Vps23:Vps28 core subcomplex and the Vps23:Vps28:Vps37 core were solved at 2.1 and 2.8 A resolution. Each subunit contains a structurally similar pair of helices that form the core. The N-terminal domain of Vps28 has a hydrophobic binding site on its surface that is conformationally dynamic. The C-terminal domain of Vps28 binds the ESCRT-II complex. The structure shows how ESCRT-I is assembled by a compact core from which the Vps23 UEV domain, the Vps28 C domain, and other domains project to bind their partners.

References

Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P GordenL Orci
Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Oct 3, 1998·Acta Crystallographica. Section D, Biological Crystallography·A T BrüngerG L Warren
Mar 25, 1999·Acta Crystallographica. Section D, Biological Crystallography·T C Terwilliger, J Berendzen
Mar 25, 1999·Acta Crystallographica. Section D, Biological Crystallography·G N MurshudovE J Dodson
Jul 27, 1999·Acta Crystallographica. Section D, Biological Crystallography·A GonzálezS Benini
Apr 27, 2000·Trends in Biochemical Sciences·G OdorizziS D Emr
Aug 10, 2000·Nature Cell Biology·M Hochstrasser
Aug 16, 2000·Acta Crystallographica. Section D, Biological Crystallography·T C Terwilliger
Aug 25, 2000·Human Molecular Genetics·D J ElliottH J Cooke
Oct 4, 2000·Nature Medicine·A HershkoA Varshavsky
Mar 27, 2001·Nature Reviews. Molecular Cell Biology·L Hicke
Jun 8, 2001·Annual Review of Biochemistry·C M Pickart
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·L VerPlankC A Carter
Jan 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Dimiter G DemirovEric O Freed
Aug 23, 2002·Molecular Cell·Elizabeth Conibear
Oct 16, 2002·Nature Structural Biology·Owen PornillosWesley I Sundquist
Dec 4, 2002·Nature Reviews. Molecular Cell Biology·David J KatzmannScott D Emr
Feb 25, 2003·Trends in Microbiology·Eric O Freed
Mar 29, 2003·Journal of Virology·Juan Martin-SerranoPaul D Bieniasz
Jul 23, 2003·Biochimica Et Biophysica Acta·Suzanne Scarlata, Carol Carter
Aug 2, 2003·Current Opinion in Cell Biology·Camilla RaiborgHarald Stenmark
Aug 6, 2003·The Journal of Cell Biology·David J KatzmannScott D Emr
Aug 6, 2003·The Journal of Cell Biology·Owen PornillosWesley I Sundquist
Aug 6, 2003·The Journal of Cell Biology·Kristi G BacheHarald Stenmark
Aug 23, 2003·Biophysical Chemistry·Marjorie Bon HommeSuzanne Scarlata
Sep 25, 2003·Cell·Bettina StrackHeinrich G Göttlinger
Sep 25, 2003·Cell·Uta K von SchwedlerWesley I Sundquist
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Linda Hicke, Rebecca Dunn
Nov 11, 2003·Trends in Biochemical Sciences·Kaisa HaglundIvan Dikic
Mar 19, 2004·The EMBO Journal·Steven L AlamWesley I Sundquist
Apr 1, 2004·Molecular Cell·Wesley I SundquistChristopher P Hill
Apr 9, 2004·Nature Reviews. Molecular Cell Biology·Jean Gruenberg, Harald Stenmark
Jun 26, 2004·The Journal of Biological Chemistry·Melissa D StuchellWesley I Sundquist
Sep 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·UNKNOWN Collaborative Computational Project, Number 4
May 1, 1997·Acta Crystallographica. Section D, Biological Crystallography·G N MurshudovE J Dodson
Aug 27, 2004·Nature·Aitor HierroJames H Hurley

❮ Previous
Next ❯

Citations

Mar 29, 2011·Plant Molecular Biology·Mojgan ShahriariSwen Schellmann
Nov 17, 2007·Cell Host & Microbe·Winfried Weissenhorn, Heinrich Göttlinger
Apr 24, 2007·Nature Reviews. Molecular Cell Biology·Roger L Williams, Sylvie Urbé
Jul 1, 2010·Nature Reviews. Molecular Cell Biology·James H Hurley, Phyllis I Hanson
May 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Evzen BouraJames H Hurley
Dec 8, 2006·Molecular Biology of the Cell·Andrea J OestreichDavid J Katzmann
Dec 14, 2007·Molecular Biology of the Cell·Bethan McDonald, Juan Martin-Serrano
Sep 16, 2006·Journal of Virology·Charles LangelierWesley I Sundquist
Jan 12, 2013·Retrovirology·Bo Meng, Andrew Ml Lever
Jun 19, 2009·Journal of Cell Science·Bethan McDonald, Juan Martin-Serrano
Jun 12, 2008·PLoS Neglected Tropical Diseases·Wen-Wei ZhangGreg Matlashewski
Mar 27, 2013·Annual Review of Biochemistry·John McCulloughWesley I Sundquist
Feb 27, 2009·Chemical Reviews·Brian A DaviesDavid J Katzmann
Jan 23, 2008·The Journal of Cell Biology·Phyllis I HansonJohn E Heuser
Dec 6, 2006·The Journal of Cell Biology·Tony ChuScott D Emr
Jul 27, 2010·Critical Reviews in Biochemistry and Molecular Biology·James H Hurley
Nov 18, 2008·Experimental Cell Research·Susanne StuffersHarald Stenmark
Jan 29, 2008·Current Opinion in Cell Biology·James H Hurley
May 24, 2006·Trends in Cell Biology·Thomas SlagsvoldHarald Stenmark
Apr 5, 2012·Journal of Molecular Biology·David TalaveraSimon C Lovell
Apr 7, 2012·Communicative & Integrative Biology·Jonathan R Mayers, Anjon Audhya
Mar 13, 2012·Structure·Monica AgromayorRoger L Williams
Jun 10, 2008·Developmental Cell·Young Jun Im, James H Hurley
May 9, 2006·Developmental Cell·Markus Babst
Jul 19, 2011·Developmental Cell·William M HenneScott D Emr
Apr 18, 2006·Structure·Sudharshan Eathiraj, David G Lambright
Mar 23, 2012·Experimental Neurobiology·Jin-A Lee, Fen-Biao Gao
Aug 30, 2011·Virus Research·Brian M FriedrichMonique R Ferguson
Apr 18, 2006·Cell·Michael S KostelanskyJames H Hurley
Mar 11, 2015·Molecular & Cellular Proteomics : MCP·Brian D DillMatthias Trost
Jul 5, 2017·Developmental and Comparative Immunology·Yu-Xuan SunBao-Jian Zhu
May 7, 2013·International Journal of Molecular Sciences·Débora L OliveiraMarcio L Rodrigues
May 21, 2008·Current Protocols in Protein Science·William Selleck, Song Tan
Jan 12, 2007·The EMBO Journal·David J GillRoger L Williams
Jun 22, 2007·Nature·Steven L Alam, Wesley I Sundquist

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.