Abstract
Retinal proteins possess vitamin A aldehyde (retinal) as a chromophore within seven transmembrane α-helices. Visible light absorption of them triggers trans-cis photoisomerization of the retinal chromophore and induces structural changes in the protein moiety, resulting in a variety of biological functions such as vision, ion transportation, and photosensing. Environmental genomics revealed that retinal proteins are widely distributed through all three biological kingdoms, eukarya, bacteria, and archaea, indicating the biological significance of their light energy conversion. In addition to their biological aspect, retinal proteins have become a focus of interest in part because of applications for optogenetics. On the basis of our results and other findings, we highlight the recent progress in structural and functional studies on retinal proteins.
References
Sep 29, 1971·Nature: New Biology·D Oesterhelt, W Stoeckenius
Apr 23, 1999·International Review of Cytology·J K Lanyi
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·J A BieszkeK A Borkovich
Feb 13, 2001·Biophysical Journal·Y SudoN Kamo
Mar 10, 2001·Environmental Microbiology·O BéjàE F DeLong
Jul 19, 2001·Nature·O BéjàE F DeLong
Jun 25, 2002·Biophysical Journal·Yuki SudoNaoki Kamo
Jun 29, 2002·Science·Georg NagelPeter Hegemann
Apr 12, 2003·The Journal of Biological Chemistry·Kazumi ShimonoNaoki Kamo
Nov 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Georg NagelErnst Bamberg
Dec 3, 2003·Biochemistry·Yuki SudoHideki Kandori
Oct 27, 2004·Biochemistry·Yuki SudoNaoki Kamo
Apr 20, 2005·Biochemistry·Yuki SudoChojiro Kojima
Aug 24, 2005·Nature Neuroscience·Edward S BoydenKarl Deisseroth
Nov 17, 2005·Journal of the American Chemical Society·Yuki SudoHideki Kandori
Sep 30, 2006·Trends in Microbiology·Adrian K SharmaW Ford Doolittle
Oct 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yuki Sudo, John L Spudich
Apr 6, 2007·Nature·Feng ZhangKarl Deisseroth
Jun 21, 2008·The Journal of Biological Chemistry·Tomomi Kitajima-IharaYuki Sudo
Jan 8, 2010·Nature·Brian Y ChowEdward S Boyden
Dec 8, 2010·The Journal of Biological Chemistry·Yuki SudoMichio Homma
Feb 4, 2011·The Journal of Biological Chemistry·Yuki SudoMichio Homma
Aug 9, 2012·The Journal of Biological Chemistry·Hiroki IriedaYuki Sudo
May 31, 2013·The Journal of Biological Chemistry·Yuki SudoShigehiko Hayashi
Jun 5, 2013·Biochimica Et Biophysica Acta·Keiichi InoueYuki Sudo
Jun 7, 2013·The Journal of Biological Chemistry·Takashi TsukamotoYuki Sudo
Feb 26, 2015·Journal of the American Chemical Society·Keiichi InoueYuki Sudo
Apr 22, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Simon DalgleishKunio Awaga
May 16, 2015·Nature Communications·Hideaki E KatoOsamu Nureki