Structural and functional surrogates of cognitive impairment at the very early stage of multiple sclerosis

Journal of the Neurological Sciences
Jean-Philippe RanjevaPatrick J Cozzone

Abstract

Following our previous reports based on parametric MRI methods (T(2)-weighted MRI, statistical mapping analysis of magnetization transfer ratio images and functional MRI) applied to a population of 18 patients with clinically isolated syndrome suggestive of multiple sclerosis, we have reviewed the possible structural and functional surrogates of MS that could explain the subtle cognitive impairment related to attention and working memory deficits evaluated with paced auditory serial addition test (PASAT). We propose that the brain substrates underlying cognitive impairment observed at the very early stage of MS are multifactorial. Several components could influence PASAT performances in patients: i) the extent of diffuse white matter damage, ii) the location of visible and non visible lesions, iii) the connectivity efficiency between distant brain functional areas involved in working memory processes and iv) the cortical reorganization. Nevertheless, individually, each of these parameters may have few influences on PASAT performance in patients. Using a multiregression model built with independent MR parameters, a very good evaluation of PASAT scores has been obtained in this limited number of patients explaining 90% of the var...Continue Reading

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Citations

May 27, 2010·Journal of Neurology·Johann SellnerMark Mühlau
Feb 10, 2010·Multiple Sclerosis : Clinical and Laboratory Research·A OzturkD S Reich
Mar 30, 2011·Neurology·M S A DeloireB Brochet
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Aug 2, 2008·Journal of the Neurological Sciences·Samantha GalluzziGiovanni B Frisoni
Jul 31, 2007·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jeffrey M Rogers, Peter K Panegyres
Sep 16, 2015·Nature Reviews. Neurology·Joanne FieldingElliot M Frohman
Dec 12, 2012·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Clelia PellicanoFrancesca Bagnato
Nov 4, 2008·Journal of the Neurological Sciences·Joanne FieldingOwen White
Aug 20, 2014·Frontiers in Human Neuroscience·Jodie R GawrylukRyan C N D'Arcy
Apr 13, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R WhelanN Tubridy
Aug 21, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Özgür YaldizliAchim Gass
Mar 3, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Mathilde DeloireBruno Brochet
Aug 13, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Claudia CodecàDiego Centonze
Jun 25, 2008·Multiple Sclerosis : Clinical and Laboratory Research·B AudoinJ P Ranjeva
Jul 26, 2008·Multiple Sclerosis : Clinical and Laboratory Research·B BrochetV Dousset
May 15, 2007·Current Opinion in Neurology·Stefanie HoffmannD Yves von Cramon
Jul 9, 2008·Current Opinion in Neurology·Maxime GuyeJean-Philippe Ranjeva
Sep 7, 2007·Journal of Neuropathology and Experimental Neurology·Jeroen J G GeurtsPaul van der Valk

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